SCHEMBL29384236

SCHEMBL29384236

O=C1c2ccccc2C(Cc2ccncc2)(Cc2ccncc2)c2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNQ2 O43526 7/20 1.00
CYP3A4 P08684 3/20 1.00
ALOX15 P16050 2/20 1.00
TSHR P16473 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2C9 P11712 2/20 1.00
ADRA1D P25100 2/20 0.63
ADRA1A P35348 2/20 0.63
ADRA1B P35368 2/20 0.63
KCNH2 Q12809 2/20 0.63
PBRM1 Q86U86 1/20 0.58
ALDH1A1 P00352 2/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C19 P33261 1/20 0.50
THPO P40225 1/20 0.50
ATM Q13315 1/20 0.49
MAPK1 P28482 1/20 0.48
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
CYP19A1 P11511 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2761225 1.00 KCNQ2 (1.00) KCNQ2CYP3A4ALOX15TSHRCYP1A2
Hydrochloric Acid SCHEMBL27203219 0.98 KCNQ2 (0.97) KCNQ2CYP3A4ALOX15TSHRCYP1A2
SCHEMBL13002451 0.91 KCNQ2 (0.82) KCNQ2CYP3A4ALOX15TSHRCYP1A2
SCHEMBL9261740 0.89 KCNQ2 (0.79) KCNQ2CYP3A4ALOX15TSHRCYP1A2
Hydrochloric Acid SCHEMBL9265822 0.87 KCNQ2 (0.77) KCNQ2CYP3A4ALOX15TSHRCYP1A2
SCHEMBL7358470 0.86 KCNQ2 (0.90) KCNQ2CYP3A4ALOX15TSHRCYP1A2
SCHEMBL31476412 0.85 KCNQ2 (0.73) KCNQ2CYP3A4ALOX15TSHRCYP1A2
SCHEMBL7547211 0.85 KCNQ2 (0.73) KCNQ2CYP3A4ALOX15TSHRCYP1A2
SCHEMBL9378991 0.81 KCNQ2 (0.68) KCNQ2CYP3A4ALOX15TSHRCYP1A2
SCHEMBL9376535 0.81 KCNQ2 (0.68) KCNQ2CYP3A4ALOX15TSHRCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709708-A1 NOVEL CARBOXAMIDE DERIVATIVES ANGELINI PHARMA S.P.A. (IT) 2026-03-18 EP disclosed
CN-121586775-A Voltage-gated sodium channel-specific peptide aptamer and application thereof 威斯康星州医药大学股份有限公司 2026-02-27 CN disclosed
EP-4695399-A2 VOLTAGE GATED SODIUM CHANNEL-SPECIFIC PEPTIDE APTAMERS AND USES THEREOF The Medical College of Wisconsin, Inc. (US) 2026-02-18 EP disclosed
US-12533425-B2 Methods and systems using peptides for targeting and mapping human nerves in image guided surgery, diagnostics and therapeutic delivery ALUME BIOSCIENCES, INC. (US) 2026-01-27 US disclosed
US-20260003178-A1 MICROSCOPE WITH SPATIAL IMAGING AND BEAM HOMOGENIZER QUIVER HOLDINGS INC (US) 2026-01-01 US disclosed
US-12508239-B2 Alcohol derivatives as Kv7 potassium channel openers for use in epilepsy or seizures H. LUNDBECK A/S (DK) 2025-12-30 US disclosed
WO-2025227157-A1 MODIFIED CELLS AND USES THEREOF UNIVERSITY OF MIAMI (US) 2025-10-30 WO disclosed
US-12422660-B2 Microscope for imaging samples within wells of multi-well plates hold by stage and beam homogenizer for homogenizing beam QUIVER HOLDINGS INC. (US) 2025-09-23 US disclosed
US-20250282725-A1 KCNQ POTENTIATORS Eii Lilly and Company 2025-09-11 US disclosed
EP-4584250-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS Biohaven Therapeutics Ltd. (VG) 2025-07-16 EP disclosed
CN-108884030-B Improved labeling of nucleophiles using bipyridines 安捷伦科技有限公司 2022-06-28 CN disclosed
WO-2022120177-A1 NERVE TARGETING PEPTIDES AND METHODS OF USE ALUME BIOSCIENCES, INC. (US) 2022-06-09 WO disclosed
EP-4007571-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS FOR USE IN EPILEPSY OR SEIZURES H. Lundbeck A/S (DK) 2022-06-08 EP disclosed
EP-4007634-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. Lundbeck A/S (DK) 2022-06-08 EP disclosed
US-11299515-B2 Optimized peptides for targeting human nerves and their use in image guided surgery, diagnostics and therapeutic THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-04-12 US disclosed
CN-114206328-A Alcohol derivatives as Kv7 potassium channel openers for use in epilepsy or seizures H.隆德贝克有限公司 2022-03-18 CN disclosed
CN-114206830-A Alcohol derivatives as Kv7 potassium channel openers H.隆德贝克有限公司 2022-03-18 CN disclosed
US-20220073464-A1 KCNQ POTENTIATORS ELI LILLY AND COMPANY 2022-03-10 US disclosed
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2022-02-24 US disclosed
US-20220040095-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS DOMPÉ FARMACEUTICI S.P.A. (IT) 2022-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250282725-A1 KCNQ POTENTIATORS KCNN3, KCNQ1, KCNN1 KCNQ2 5/4885CYP3A4 2954/4885ALOX15 2723/4885
US-20260003178-A1 MICROSCOPE WITH SPATIAL IMAGING AND BEAM HOMOGENIZER MYO1F, ASF1A, WASF2 KCNQ2 2184/4885CYP3A4 4699/4885ALOX15 4159/4885
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION MKI67, MYLK2, MYH2 KCNQ2 4607/4885CYP3A4 4880/4885ALOX15 3805/4885
US-12533425-B2 Methods and systems using peptides for targeting and mapping human nerves in image guided surgery, diagnostics and therapeutic delivery NGLY1, VGF, GAP43 KCNQ2 1234/4885CYP3A4 4828/4885ALOX15 4559/4885
US-20220073464-A1 KCNQ POTENTIATORS KCNN3, KCNQ1, KCNN1 KCNQ2 5/4885CYP3A4 2954/4885ALOX15 2723/4885
US-20220040095-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS OTC, AQP4, SLC26A4 KCNQ2 2082/4885CYP3A4 4486/4885ALOX15 462/4885
US-12508239-B2 Alcohol derivatives as Kv7 potassium channel openers for use in epilepsy or seizures KCNN3, KCNN1, KCNN2 KCNQ2 6/4885CYP3A4 3532/4885ALOX15 2730/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.