Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801523 | 0.85 | LMNA (0.45) | LMNAHTTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL1805257 | 0.85 | LMNA (0.45) | LMNAHTTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL3999880 | 0.82 | LMNA (0.49) | LMNAHTTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL2942653 | 0.80 | HPGD (0.42) | LMNAHTTALDH1A1KMT2AMAPT | |
| SCHEMBL4037859 | 0.80 | L3MBTL1 (0.48) | LMNAHTTSMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL4037858 | 0.80 | L3MBTL1 (0.48) | LMNAHTTSMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL2934172 | 0.79 | CYP2C9 (0.53) | LMNAHTTSMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL2942498 | 0.77 | AVPR1A (0.53) | LMNAALDH1A1CYP2C9KMT2AMEN1 | |
| SCHEMBL2943001 | 0.77 | MEN1 (0.39) | CYP2C19KMT2AMEN1 | |
| SCHEMBL2941843 | 0.77 | CYP2C9 (0.45) | HTTSMN1; SMN2ALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730147-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2010-02-03 | — | — | EP | claimed |