Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037858 | 1.00 | L3MBTL1 (0.48) | L3MBTL1LMNAEPHX2ALDH1A1MEN1 | |
| SCHEMBL3918973 | 0.86 | L3MBTL1 (0.46) | L3MBTL1LMNAEPHX2ALDH1A1MEN1 | |
| SCHEMBL3918975 | 0.86 | L3MBTL1 (0.46) | L3MBTL1LMNAEPHX2ALDH1A1MEN1 | |
| SCHEMBL4038204 | 0.82 | EPHX2 (0.47) | L3MBTL1EPHX2ALDH1A1MEN1KMT2A | |
| SCHEMBL4041475 | 0.81 | MMP2 (0.39) | L3MBTL1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL3927380 | 0.81 | CYP2D6 (0.45) | L3MBTL1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL4032408 | 0.80 | ALDH1A1 (0.52) | LMNAEPHX2ALDH1A1MEN1KMT2A | |
| SCHEMBL2938747 | 0.80 | LMNA (0.47) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3918144 | 0.79 | MMP2 (0.53) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL4035567 | 0.78 | LMNA (0.48) | LMNAALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |