Arbutamine

Arbutamine

SCHEMBL29390265

Oc1ccc(CCCCNC[C@H](O)c2ccc(O)c(O)c2)cc1

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 14/20 0.61
ADRB1 P08588 7/20 0.61
ADRB3 P13945 4/20 0.56
DRD2 P14416 4/20 0.55
DRD3 P35462 4/20 0.55
DRD4 P21917 3/20 0.55
MEN1 O00255 3/20 0.55
KMT2A Q03164 3/20 0.55
ALOX15 P16050 2/20 0.55
KDM4E B2RXH2 2/20 0.55
ADRA2B P18089 2/20 0.55
ADRA1D P25100 2/20 0.55
ADRA1A P35348 2/20 0.55
CYP1A2 P05177 2/20 0.55
CYP3A4 P08684 2/20 0.55
CYP2D6 P10635 2/20 0.55
TSHR P16473 2/20 0.55
MAPK1 P28482 2/20 0.55
HTR1A P08908 1/20 0.55
CHRM5 P08912 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arbutamine SCHEMBL3699485 1.00 ADRB2 (0.61) ADRB2ADRB1ADRB3DRD2DRD3
Arbutamine SCHEMBL29929016 1.00 ADRB2 (0.61) ADRB2ADRB1ADRB3DRD2DRD3
Arbutamine SCHEMBL20769823 1.00 ADRB2 (0.61) ADRB2ADRB1ADRB3DRD2DRD3
Arbutamine SCHEMBL521645 1.00 ADRB2 (0.61) ADRB2ADRB1ADRB3DRD2DRD3
Arbutamine SCHEMBL7295080 0.99 ADRB2 (0.60) ADRB2ADRB1ADRB3DRD2DRD3
Arbutamine SCHEMBL40757 0.99 ADRB2 (0.60) ADRB2ADRB1ADRB3DRD2DRD3
Arbutamine SCHEMBL4327619 0.97 ADRB2 (0.59) ADRB2ADRB1ADRB3DRD2DRD3
Arbutamine SCHEMBL7870502 0.94 ADRB2 (0.58) ADRB2ADRB1ADRB3DRD2DRD3
Hexoprenaline SCHEMBL121449 0.85 ADRB2 (0.72) ADRB2ADRB1ADRB3DRD2DRD3
Hexoprenaline SCHEMBL32668781 0.85 ADRB2 (0.72) ADRB2ADRB1ADRB3DRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025265094-A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-12-26 WO disclosed
US-20220226310-A1 Bio-Based Medicines and Methods of Increasing Patient Compliance RDE PHARMA 2022-07-21 US disclosed
US-11246873-B2 Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate THE SCRIPPS RESEARCH INSTITUTE (US) 2022-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220226310-A1 Bio-Based Medicines and Methods of Increasing Patient Compliance PAH, BPGM, TPMT ADRB2 1682/4885ADRB1 1330/4885ADRB3 1289/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.