Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | F2R | P25116 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254622 | 0.85 | FFAR1 (0.43) | F2RALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL29480975 | 0.81 | F2R (0.43) | F2RALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL29540504 | 0.81 | PRNP (0.56) | PRNPALDH1A1ALOX15FABP4KMT2A | |
| SCHEMBL241422 | 0.81 | PRNP (0.56) | PRNPALDH1A1ALOX15FABP4KMT2A | |
| SCHEMBL3309613 | 0.80 | ALDH1A1 (0.53) | ALDH1A1ALOX15FABP4L3MBTL1KMT2A | |
| SCHEMBL6272437 | 0.79 | PRNP (0.47) | PRNPALDH1A1ALOX15FABP4KMT2A | |
| SCHEMBL551896 | 0.78 | ALDH1A1 (0.47) | PRNPF2RALDH1A1FABP4KMT2A | |
| SCHEMBL29480920 | 0.78 | TSHR (0.53) | F2RALDH1A1ALOX15KMT2AMEN1 | |
| SCHEMBL31582514 | 0.76 | PRNP (0.45) | PRNPALDH1A1ALOX15FABP4KMT2A | |
| SCHEMBL61847 | 0.76 | CES2 (0.47) | KMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174278-B | Dihydroorotate dehydrogenase inhibitors | 詹森生物科技公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-114174278-A | Dihydroorotate dehydrogenase inhibitors | 詹森生物科技公司 | 2022-03-11 | — | — | CN | disclosed |
| EP-3956320-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Janssen Biotech, Inc. (US) | 2022-02-23 | — | — | EP | disclosed |