Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | RXRB | P28702 | 12/20 | 0.40 |
| ▸ | RXRA | P19793 | 11/20 | 0.40 |
| ▸ | RXRG | P48443 | 9/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL77791 | 0.83 | ACHE (0.47) | HDAC8RXRBRXRAALDH1A1TP53 | |
| SCHEMBL5260445 | 0.75 | HTR2C (0.41) | HDAC8ALDH1A1TP53SMN1; SMN2LMNA | |
| SCHEMBL11103938 | 0.75 | RXRB (0.45) | RXRBRXRARXRGGABRA1GABRB2 | |
| SCHEMBL24237327 | 0.71 | GABRA1 (0.42) | HDAC8RXRBRXRARXRGGABRA1 | |
| SCHEMBL2543696 | 0.70 | ALDH1A1 (0.63) | ALDH1A1TP53SMN1; SMN2LMNAMLYCD | |
| SCHEMBL16776735 | 0.69 | RXRB (0.38) | RXRBRXRARXRGGABRA1GABRB2 | |
| SCHEMBL7931675 | 0.68 | GABRA1 (0.44) | HDAC8RXRBRXRARXRGGABRA1 | |
| SCHEMBL11473066 | 0.68 | RXRA (0.62) | HDAC8RXRBRXRARXRGGABRA1 | |
| SCHEMBL22235910 | 0.67 | ALDH1A1 (0.45) | HDAC8RXRBRXRARXRGALDH1A1 | |
| SCHEMBL11211561 | 0.67 | AKR1C3 (0.50) | RXRBRXRARXRGGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149688-A2 | ANTITUMORAL COMPOUNDS | PHARMA MAR, S.A. (ES) | 2010-12-29 | — | — | WO | disclosed |