Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL77791 | 0.89 | ACHE (0.47) | HTR2CALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL3933066 | 0.76 | HTR2C (0.47) | HTR2CALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL16934132 | 0.76 | ALDH1A1 (0.47) | HTR2CALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL578453 | 0.76 | ALDH1A1 (0.47) | HTR2CALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL5262282 | 0.76 | MTNR1A (0.44) | HTR2CALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL2850199 | 0.76 | HTR2C (0.47) | HTR2CALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL2543696 | 0.75 | ALDH1A1 (0.63) | HTR2CALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL2940747 | 0.75 | HDAC8 (0.48) | ALDH1A1LMNATP53SMN1; SMN2MLYCD | |
| SCHEMBL3922657 | 0.74 | MEN1 (0.45) | HTR2CALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL3930203 | 0.73 | HTR2C (0.42) | HTR2CALDH1A1LMNATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |