Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803072 | 0.86 | GRM5 (0.48) | GRM5ALDH1A1 | |
| SCHEMBL1803348 | 0.85 | GRM5 (0.43) | GRM5ALDH1A1 | |
| SCHEMBL2938912 | 0.84 | CYP3A4 (0.42) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2934783 | 0.82 | CCR5 (0.40) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2932813 | 0.82 | MEN1 (0.43) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2942516 | 0.81 | SMN1; SMN2 (0.48) | ALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL1803451 | 0.81 | ALDH1A1 (0.44) | GRM5ALDH1A1 | |
| SCHEMBL2943556 | 0.81 | LMNA (0.49) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2941205 | 0.80 | MEN1 (0.44) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2941530 | 0.79 | HPGD (0.43) | ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730147-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2010-02-03 | — | — | EP | claimed |