Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | USP19 | O94966 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801308 | 0.87 | CCR5 (0.49) | LMNASMN1; SMN2MAPK1USP19ALDH1A1 | |
| SCHEMBL2934783 | 0.85 | CCR5 (0.40) | LMNASMN1; SMN2ALDH1A1KMT2ACCR5 | |
| SCHEMBL2941205 | 0.82 | MEN1 (0.44) | LMNASMN1; SMN2MAPK1ALDH1A1KDM4E | |
| SCHEMBL2938912 | 0.82 | CYP3A4 (0.42) | LMNASMN1; SMN2ALDH1A1KDM4EKMT2A | |
| SCHEMBL2932813 | 0.82 | MEN1 (0.43) | LMNASMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL4041825 | 0.82 | NPSR1 (0.43) | LMNASMN1; SMN2ALDH1A1KDM4EKMT2A | |
| SCHEMBL1798595 | 0.82 | LMNA (0.46) | LMNASMN1; SMN2MAPK1USP19ALDH1A1 | |
| SCHEMBL2940845 | 0.81 | GRM5 (0.47) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL1799397 | 0.80 | LMNA (0.46) | LMNASMN1; SMN2MAPK1USP19ALDH1A1 | |
| SCHEMBL5667080 | 0.80 | LMNA (0.49) | LMNASMN1; SMN2MAPK1USP19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730147-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2010-02-03 | — | — | EP | claimed |