Adhyperforin

Adhyperforin

SCHEMBL29410027

C1CCC(NC2CCCCC2)CC1.CCC(C)C(=O)[C@]12C(=O)[C@](CC=C(C)C)(C[C@H](CC=C(C)C)[C@@]1(C)CCC=C(C)C)C(=O)C(CC=C(C)C)=C2O

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ SLC6A2 P23975 2/20 0.89
▸ SLC6A4 P31645 2/20 0.89
▸ SLC6A3 Q01959 2/20 0.89
▸ SIRT2 Q8IXJ6 5/20 0.64
▸ SIRT1 Q96EB6 5/20 0.64
▸ PTGES O14684 2/20 0.64
▸ NR1I2 O75469 1/20 0.64
▸ CYP3A4 P08684 1/20 0.64
▸ DLAT P10515 1/20 0.64
▸ MAPT P10636 1/20 0.64
▸ SMN1; SMN2 Q16637 1/20 0.64
▸ ACHE P22303 9/20 0.52
▸ POLL Q9UGP5 3/20 0.40
▸ STAT1 P42224 1/20 0.40
▸ MET P08581 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7622838 0.93 SLC6A2 (0.77) SLC6A2SLC6A4SLC6A3SIRT2SIRT1
SCHEMBL878771 0.92 SLC6A2 (0.75) SLC6A2SLC6A4SLC6A3SIRT2SIRT1
SCHEMBL25184456 0.86 SLC6A2 (0.85) SLC6A2SLC6A4SLC6A3SIRT2SIRT1
SCHEMBL14577497 0.85 SIRT2 (0.86) SLC6A2SLC6A4SLC6A3SIRT2SIRT1
SCHEMBL21907266 0.85 SIRT2 (0.86) SLC6A2SLC6A4SLC6A3SIRT2SIRT1
SCHEMBL98723 0.85 SIRT2 (0.86) SLC6A2SLC6A4SLC6A3SIRT2SIRT1
SCHEMBL12634392 0.85 SIRT2 (0.86) SLC6A2SLC6A4SLC6A3SIRT2SIRT1
SCHEMBL14233249 0.85 SIRT2 (0.86) SLC6A2SLC6A4SLC6A3SIRT2SIRT1
SCHEMBL15694967 0.85 SIRT2 (0.86) SLC6A2SLC6A4SLC6A3SIRT2SIRT1
SCHEMBL7871338 0.84 SIRT2 (0.85) SLC6A2SLC6A4SLC6A3SIRT2SIRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250375398-A1 COMBINATION THERAPIES FOR THE TREATMENT OF VIRAL INFECTIONS FLAGSHIP PIONEERING INNOVATIONS VI LLC (US) 2025-12-11 — — US claimed
US-20250302797-A1 COMBINATION THERAPIES FOR TREATING INFLAMMATION FLAGSHIP PIONEERING INNOVATIONS VI LLC (US) 2025-10-02 — — US claimed
WO-2024035859-A1 COMBINATION THERAPIES FOR TREATING INFLAMMATION FLAGSHIP PIONEERING INNOVATIONS VI, LLC (US) 2024-02-15 — — WO claimed
WO-2023250110-A1 COMBINATION THERAPIES FOR THE TREATMENT OF VIRAL INFECTIONS FLAGSHIP PIONEERING INNOVATIONS VI, LLC (US) 2023-12-28 — — WO claimed
US-11654121-B1 Combination therapies for the treatment of viral infections FLAGSHIP PIONEERING INNOVATIONS VI, LLC (US) 2023-05-23 — — US claimed
US-20220242809-A1 METHODS FOR ISOLATING ESSENTIAL OILS, PHYTOCHEMICALS AND PHARMACEUTICALLY ACTIVE COMPONENTS FROM BIOMASS AND RECONSTITUTING SYNTHETIC FORMULATIONS COMPRISING SAME ATLAS HEMP COMPANY LLC (US) 2022-08-04 — — US claimed
US-11261477-B2 Glycosylation modification of bioactive compounds and drugs by plant glycosyltransferases (UGTs) UNIVERSITY OF NORTH TEXAS (US) 2022-03-01 — — US claimed
US-20260118894-A1 PRECISION CONTROL AND CHARACTERIZATION OF DISPENSED SUBSTANCES ALTOPA INC (US) 2026-04-30 — — US disclosed
US-12524026-B2 Precision control and characterization of dispensed substances ALTOPA, INC. (US) 2026-01-13 — — US disclosed
EP-3231446-B1 COMPOSITIONS AND METHODS FOR SELECTIVE DELIVERY OF OLIGONUCLEOTIDE MOLECULES TO SPECIFIC NEURON TYPES PALOMO LTD (CY) 2026-01-07 — — EP disclosed
US-20250375398-A1 COMBINATION THERAPIES FOR THE TREATMENT OF VIRAL INFECTIONS FLAGSHIP PIONEERING INNOVATIONS VI LLC (US) 2025-12-11 — — US disclosed
EP-4633654-A1 A SYNERGISTIC COMPOSITION Toker, Nezihe Filiz (TR) 2025-10-22 — — EP disclosed
US-20250302797-A1 COMBINATION THERAPIES FOR TREATING INFLAMMATION FLAGSHIP PIONEERING INNOVATIONS VI LLC (US) 2025-10-02 — — US disclosed
EP-3328835-B1 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE ARENA PHARM INC (US) 2022-10-12 — — EP disclosed
EP-3500570-B1 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE ARENA PHARM INC (US) 2022-10-05 — — EP disclosed
US-20220242809-A1 METHODS FOR ISOLATING ESSENTIAL OILS, PHYTOCHEMICALS AND PHARMACEUTICALLY ACTIVE COMPONENTS FROM BIOMASS AND RECONSTITUTING SYNTHETIC FORMULATIONS COMPRISING SAME ATLAS HEMP COMPANY LLC (US) 2022-08-04 — — US disclosed
US-11395824-B2 5-HT2C receptor agonists and compositions and methods of use ARENA PHARMACEUTICALS, INC. (US) 2022-07-26 — — US disclosed
WO-2022153322-A1 MODIFIED MIR-135, CONJUGATED FORM THEREOF, AND USES OF SAME YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2022-07-21 — — WO disclosed
US-11274158-B2 Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators FLAGSHIP PIONEERING INNOVATIONS V, INC. (US) 2022-03-15 — — US disclosed
US-11261477-B2 Glycosylation modification of bioactive compounds and drugs by plant glycosyltransferases (UGTs) UNIVERSITY OF NORTH TEXAS (US) 2022-03-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11395824-B2 5-HT2C receptor agonists and compositions and methods of use HTR2C, HTR2A, HCRTR2 SLC6A2 106/4885SLC6A4 179/4885SLC6A3 162/4885
US-20250302797-A1 COMBINATION THERAPIES FOR TREATING INFLAMMATION TNF, MMP8, TSLP SLC6A2 4018/4885SLC6A4 4235/4885SLC6A3 4213/4885
US-11654121-B1 Combination therapies for the treatment of viral infections HAVCR2, EIF2AK2, MAVS SLC6A2 4006/4885SLC6A4 4071/4885SLC6A3 4376/4885
US-20260118894-A1 PRECISION CONTROL AND CHARACTERIZATION OF DISPENSED SUBSTANCES PIEZO1, HTR3D, JAK2 SLC6A2 341/4885SLC6A4 141/4885SLC6A3 378/4885
US-20250375398-A1 COMBINATION THERAPIES FOR THE TREATMENT OF VIRAL INFECTIONS HAVCR2, EIF2AK2, MAVS SLC6A2 4006/4885SLC6A4 4071/4885SLC6A3 4376/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback