Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.34 |
| ▸ | TUBB | P07437 | 5/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12700187 | 0.89 | KDM4E (0.40) | KDM4EALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL52405 | 0.78 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL29366129 | 0.78 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL9825607 | 0.77 | ALDH1A1 (0.40) | KDM4EALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL11610147 | 0.77 | TUBB4A (0.47) | KDM4EALDH1A1MAPK1SMN1; SMN2TUBB4A | |
| Iodide SCHEMBL5967814 | 0.75 | ALDH1A1 (0.94) | KDM4EALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL15499817 | 0.74 | MAPT (0.40) | MAPTTSHR | |
| SCHEMBL16747883 | 0.71 | KDM4E (0.58) | KDM4EALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL15498566 | 0.71 | MAPT (0.35) | KDM4EMAPTTSHR | |
| SCHEMBL30099100 | 0.70 | TNKS (0.41) | KDM4EALDH1A1MAPTTSHRADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103153975-B | Novel naphthoquinones for use in the treatment of disease | Hangzhou Yier Biological Technology Co.,Ltd. (CN) | 2016-01-20 | — | — | CN | disclosed |
| US-8871802-B2 | Naphthoquinones for disease therapies | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-20130150437-A1 | NAPHTHOQUINONES FOR DISEASE THERAPIES | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2013-06-13 | — | — | US | disclosed |
| CN-103153975-A | Novel naphthoquinones for use in the treatment of disease | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO LTD | 2013-06-12 | — | — | CN | disclosed |
| WO-2012024818-A1 | NOVEL ANPHTHOQUINONES FOR DISEASE THERAPIES | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2012-03-01 | — | — | WO | disclosed |
| EP-1093456-B1 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIV NORTH CAROLINA (US) | 2003-12-17 | — | — | EP | disclosed |
| US-6337346-B1 | BENZODITHIOPHENE DERIVATIVES | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2002-01-08 | — | — | US | disclosed |
| EP-1093456-A2 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2001-04-25 | — | — | EP | disclosed |
| US-6174913-B1 | TREATING TUMOR BY ADMINISTERING COMPOUNDS E.G.:2-ACETYL-NAPHTHO(2,3-B)THIOPHENE-4,9-DIONE; 2,7-DIACETYL-NAPHTHO(2,3-B)THIOPHENE-4,9-DIONE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-01-16 | — | — | US | disclosed |
| WO-1999062909-A9 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIV NORTH CAROLINA (US) | 2000-04-27 | — | — | WO | disclosed |
| WO-1999062909-A2 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150437-A1 | NAPHTHOQUINONES FOR DISEASE THERAPIES | NQO1, NME2, CYP27B1 | KDM4E 2313/4885ALDH1A1 282/4885MAPK1 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.