⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Beta-Alanine SCHEMBL393586 | 0.86 | LMNA (0.35) | — | |
| SCHEMBL11123306 | 0.82 | ALOX15 (0.31) | — | |
| SCHEMBL393855 | 0.79 | — | — | |
| SCHEMBL5483007 | 0.78 | — | — | |
| SCHEMBL84208 | 0.78 | — | — | |
| SCHEMBL393856 | 0.77 | — | — | |
| SCHEMBL28401911 | 0.77 | — | — | |
| SCHEMBL27806374 | 0.72 | CES2 (0.46) | — | |
| Acrylic Acid SCHEMBL11909823 | 0.71 | LMNA (0.46) | — | |
| SCHEMBL9224140 | 0.69 | THRB (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9737409-B2 | Prosthetic intervertebral discs implantable by minimally invasive, posterior approach, surgical techniques | SPINAL KINETICS INC. (US) | 2017-08-22 | — | — | US | disclosed |
| US-9687353-B2 | Prosthetic intervertebral discs having balloon-based fillable cores that are implantable by minimally invasive surgical techniques | SPINAL KINETICS, INC. | 2017-06-27 | — | — | US | disclosed |
| US-8795374-B2 | Prosthetic intervertebral discs that are implantable by minimally invasive surgical techniques and that have cores that are insertable in situ using end plate guideways | SPINAL KINETICS INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8403987-B2 | Prosthetic intervertebral discs having compressible core elements bounded by fiber-containing membranes | SPINAL KINETICS INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-8361154-B2 | Temporarily bound prosthetic intervertebral discs implantable by minimally invasive surgical techniques | SPINAL KINETICS INC. (US) | 2013-01-29 | — | — | US | disclosed |
| WO-2010126915-A1 | PROSTHETIC INTERVERTEBRAL DISCS IMPLANTABLE BY MINIMALLY INVASIVE SURGICAL TECHNIQUES | SPINAL KINETICS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| US-20090125112-A1 | Prosthetic Intervertebral Discs Implantable By Minimally Invasive, Posterior Approach, Surgical Techniques | SPINAL KINETICS, INC. (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090118835-A1 | Prosthetic Intervertebral Discs Having Rotatable, Expandable Cores That Are Implantable Using Minimally Invasive Surgical Techniques | SPINAL KINETICS, INC. (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090118834-A1 | Expandable Prosthetic Intervertebral Discs That Are Implantable By Minimally Invasive Surgical Techniques | SPINAL KINETICS, INC. (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090093884-A1 | Prosthetic Intervertebral Discs Having Expandable Cores That Are Implantable Using Minimally Invasive Surgical Techniques | SPINAL KINETICS, INC. (US) | 2009-04-09 | — | — | US | disclosed |
| US-20080077242-A1 | Prosthetic intervertebral discs having compressible core elements bounded by fiber-containing membranes | ISOTIS ORTHOBIOLOGICS, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20070270561-A1 | SILICONE HYDROGELS BASED ON VINYL CARBONATE ENDCAPPED FLUORINATED SIDE CHAIN POLYSILOXANES | SALIX PHARMACEUTICALS, INC. | 2007-11-22 | — | — | US | disclosed |
| WO-2007124078-A2 | PROSTHETIC INTERVERTEBRAL DISCS IMPLANTABLE BY MINIMALLY INVASIVE SURGICAL TECHNIQUES | SPINAL KINETICS, INC. (US) | 2007-11-01 | — | — | WO | disclosed |
| US-7268198-B2 | Silicone hydrogel contact lenses | BAUSCH & LOMB INCORPORATED (US) | 2007-09-11 | — | — | US | disclosed |
| US-20050165187-A1 | Silicone hydrogels based on vinyl carbonate endcapped fluorinated side chain polysiloxanes | BAUSCH HEALTH MAGYARORSZAG KFT (A/K/A BAUSCH HEALTH HUNGARY LLC) (HU) | 2005-07-28 | — | — | US | disclosed |
| US-6891010-B2 | Silicone hydrogels based on vinyl carbonate endcapped fluorinated side chain polysiloxanes | BAUSCH & LOMB INCORPORATED (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1458776-A1 | SILICONE HYDROGELS BASED ON VINYL CARBONATE ENDCAPPED FLUORINATED SIDE CHAIN POLYSILOXANES | BAUSCH & LOMB INCORPORATED (US) | 2004-09-22 | — | — | EP | disclosed |
| US-20030125497-A1 | Silicone hydrogels based on vinyl carbonate endcapped fluorinated side chain polysiloxanes | 1261229 B.C. LTD. (CA) | 2003-07-03 | — | — | US | disclosed |
| WO-2003037944-A1 | SILICONE HYDROGELS BASED ON VINYL CARBONATE ENDCAPPED FLUORINATED SIDE CHAIN POLYSILOXANES | BAUSCH & LOMB INCORPORATED (US) | 2003-05-08 | — | — | WO | disclosed |
| EP-0396364-B1 | Copolymers of vinyl carbonate and vinyl carbamate as contact lens material | BAUSCH & LOMB (US) | 1997-06-11 | — | — | EP | disclosed |