Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ac-430. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 known ✓ | O60674 | 3/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.98 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.98 |
| ▸ | JAK1 | P23458 | 3/20 | 0.98 |
| ▸ | TYK2 | P29597 | 3/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.98 |
| ▸ | JAK3 | P52333 | 3/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | AURKA | O14965 | 10/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.60 |
| ▸ | SRC | P12931 | 5/20 | 0.59 |
| ▸ | GSK3B | P49841 | 5/20 | 0.59 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.59 |
| ▸ | GSK3A | P49840 | 1/20 | 0.59 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ac-430 SCHEMBL174751 | 1.00 | JAK2 (0.98) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| Ac-430 SCHEMBL256569 | 0.99 | JAK2 (1.00) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| Ac-430 SCHEMBL29578828 | 0.99 | JAK2 (1.00) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| Ac-430 SCHEMBL29522676 | 0.99 | JAK2 (1.00) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| Ac-430 SCHEMBL173827 | 0.99 | JAK2 (1.00) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| Ac-430 SCHEMBL164912 | 0.99 | JAK2 (1.00) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| Ac-430 SCHEMBL175041 | 0.99 | JAK2 (1.00) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| Ac-430 SCHEMBL173361 | 0.98 | JAK2 (0.98) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| Ac-430 SCHEMBL29522921 | 0.98 | JAK2 (0.98) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| Ac-430 SCHEMBL186942 | 0.98 | JAK2 (0.98) | JAK2CYP3A4CYP2C8CYP2C9JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122091619-A | Pt-based catalyst, preparation method and application | — | 2026-05-26 | — | — | CN | claimed |
| CN-119050390-A | Preparation and application of metal oxide modified carbon-supported Pt-based ordered alloy catalyst | 厦门紫金新能源新材料科技有限公司 | 2024-11-29 | — | — | CN | claimed |
| CN-118894842-A | Organic compound, organic photoelectric element containing same and application | 上海蓝屏医疗科技有限公司 | 2024-11-05 | — | — | CN | claimed |
| CN-221740788-U | In-situ thermal regeneration asphalt pavement | 西安公路研究院有限公司 | 2024-09-20 | — | — | CN | claimed |
| CN-115959659-A | Activated carbon particles and preparation method thereof | 上海船舶工艺研究所(中国船舶集团有限公司第十一研究所) | 2023-04-14 | — | — | CN | claimed |
| CN-113213813-B | Asphalt concrete applied to prefabricated elastic ballast bed structure, sample and preparation method | 东南大学 | 2022-06-07 | — | — | CN | claimed |
| CN-122091619-A | Pt-based catalyst, preparation method and application | — | 2026-05-26 | — | — | CN | disclosed |
| US-20260139240-A1 | SUBTILASE CYTOTOXIN B SUBUNIT MUTANT | GRIFFITH UNIVERSITY (AU) | 2026-05-21 | — | — | US | disclosed |
| WO-2026106883-A1 | BINDER COMPOSITIONS AND METHODS OF MAKING THE SAME | HONEYWELL INTERNATIONAL INC. (US) | 2026-05-21 | — | — | WO | disclosed |
| US-20260132289-A1 | BINDER COMPOSITIONS AND METHODS OF MAKING THE SAME | HONEYWELL INTERNATIONAL INC. (US) | 2026-05-14 | — | — | US | disclosed |
| US-12618934-B2 | Methods and systems for validating locations | Khalifa University of Science and Technology (AE) | 2026-05-05 | — | — | US | disclosed |
| US-12570856-B2 | Pigmentable, non-asphalt based, sealant composition and methods of production and use | ADVENTUS MATERIAL STRATEGIES, LLC (US) | 2026-03-10 | — | — | US | disclosed |
| US-20260008890-A1 | BITUMEN COMPOSITIONS COMPRISING LIGNIN | NEW ENERGY BLUE LLC (US) | 2026-01-08 | — | — | US | disclosed |
| CN-114585673-A | Asphalt additive | 奥升德功能材料运营有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-114486609-A | Detection method for segregation degree of asphalt mixture | 中交一公局集团有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-11312928-B2 | Detergent composition comprising an acidic sophorose lipid and fatty acid salt mixture | SARAYA CO., LTD. (JP) | 2022-04-26 | — | — | US | disclosed |
| US-20220112129-A1 | ASPHALT ADDITIVES | ASCEND PERFORMANCE MATERIALS OPERATIONS LLC (US) | 2022-04-14 | — | — | US | disclosed |
| WO-2022076149-A1 | ASPHALT ADDITIVES | ASCEND PERFORMANCE MATERIALS OPERATIONS LLC (US) | 2022-04-14 | — | — | WO | disclosed |
| US-20220071955-A1 | Methods of Treatment, Prevention and Diagnosis | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2022-03-10 | — | — | US | disclosed |
| US-20220061324-A1 | PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS | SYNGENTA CROP PROTECTION AG (CH) | 2022-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260008890-A1 | BITUMEN COMPOSITIONS COMPRISING LIGNIN | BRWD1, LCT, SETD7 | JAK2 693/4885CYP3A4 3048/4885CYP2C8 2099/4885 |
| US-20260139240-A1 | SUBTILASE CYTOTOXIN B SUBUNIT MUTANT | ENGASE, SPPL2B, NEU2 | JAK2 4725/4885CYP3A4 3613/4885CYP2C8 3398/4885 |
| US-12570856-B2 | Pigmentable, non-asphalt based, sealant composition and methods of production and use | CROCC, RARG, MAPT | JAK2 2304/4885CYP3A4 4448/4885CYP2C8 4456/4885 |
| US-11312928-B2 | Detergent composition comprising an acidic sophorose lipid and fatty acid salt mixture | WASHC4, WASHC5, DEGS1 | JAK2 3827/4885CYP3A4 3225/4885CYP2C8 3114/4885 |
| US-20220071955-A1 | Methods of Treatment, Prevention and Diagnosis | TARDBP, GRN, FUS | JAK2 4876/4885CYP3A4 4752/4885CYP2C8 4841/4885 |
| US-20220061324-A1 | PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS | DDT, ACHE, AADAC | JAK2 3470/4885CYP3A4 1989/4885CYP2C8 1724/4885 |
| US-12618934-B2 | Methods and systems for validating locations | FURIN, PROKR2, SRMS | JAK2 6/4885CYP3A4 4293/4885CYP2C8 3533/4885 |
| US-20260132289-A1 | BINDER COMPOSITIONS AND METHODS OF MAKING THE SAME | L3MBTL3, AS3MT, HNRNPM | JAK2 2864/4885CYP3A4 3136/4885CYP2C8 4436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.