SCHEMBL29427697

SCHEMBL29427697

CC(C)c1cccc2c1OC(C(C)C)C(=S)N2CC(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.33
MEN1 O00255 2/20 0.33
BRD4 O60885 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
ALOX15 P16050 2/20 0.32
HSD17B10 Q99714 1/20 0.32
LMNA P02545 1/20 0.32
MME P08473 3/20 0.31
ACE P12821 3/20 0.31
NOTUM Q6P988 1/20 0.31
EGFR P00533 1/20 0.31
PTGES O14684 1/20 0.31
APEX1 P27695 1/20 0.31
HTR7 P34969 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4969187 1.00 KMT2A (0.33) KMT2AMEN1BRD4TDP1ALOX15
SCHEMBL1219564 1.00 KMT2A (0.33) KMT2AMEN1BRD4TDP1ALOX15
SCHEMBL4972064 1.00 KMT2A (0.33) KMT2AMEN1BRD4TDP1ALOX15
SCHEMBL4972145 0.88 EGFR (0.37) KMT2AMEN1LMNAMMEACE
SCHEMBL10359001 0.87 POLB (0.38) KMT2AMEN1TDP1ALOX15HSD17B10
SCHEMBL10359000 0.87 POLB (0.38) KMT2AMEN1TDP1ALOX15HSD17B10
SCHEMBL1201887 0.87 BRD4 (0.43) KMT2AMEN1BRD4ALOX15HSD17B10
SCHEMBL10359065 0.87 BRD4 (0.34) KMT2AMEN1BRD4ALOX15HSD17B10
SCHEMBL4970660 0.86 EGFR (0.36) KMT2AMEN1TDP1NOTUMEGFR
SCHEMBL10359099 0.86 MEN1 (0.32) KMT2AMEN1EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120114457-A Aldose reductase inhibitors for the treatment of phosphomannomutase 2 deficiency 应用治疗公司 2025-06-10 CN disclosed
CN-119971038-A Compositions and methods for treating galactosylation 应用治疗公司 2025-05-13 CN disclosed
US-20250140406-A1 CLASSIFYING TUMORS AND PREDICTING RESPONSIVENESS INSIGHT MOLECULAR DIAGNOSTICS INC. 2025-05-01 US disclosed
CN-114667139-B Aldose reductase inhibitors for the treatment of phosphomannomutase 2 deficiency 应用治疗公司 2025-03-28 CN disclosed
EP-4525833-A2 VETERINARY PHARMACEUTICAL FORMULATIONS Increvet, Inc. (US) 2025-03-26 EP disclosed
CN-119633117-A Compositions and methods for treating galactosylation 应用治疗公司 2025-03-18 CN disclosed
CN-111065392-B Compositions and methods for treating galactosylation 应用治疗公司 2024-10-25 CN disclosed
EP-4417260-A2 COMPOSITIONS AND METHODS FOR TREATING GALACTOSEMIA Applied Therapeutics, Inc. (US) 2024-08-21 EP disclosed
US-20240238288-A1 ALDOSE REDUCTASE INHIBITORS FOR TREATING SORBITOL DEHYDROGENASE DEFICIENCY BARCLAYS BANK PLC (GB) 2024-07-18 US disclosed
US-20230372374-A1 VETERINARY PHARMACEUTICAL FORMULATIONS INCREVET, INC. 2023-11-23 US disclosed
US-20230121312-A1 ALDOSE REDUCTASE INHIBITORS FOR TREATING SORBITOL DEHYDROGENASE DEFICIENCY Applied Therapeutics, Inc. 2023-04-20 US disclosed
US-11590131-B2 Compositions and methods for treating galactosemia Applied Therapeutics, Inc. (US) 2023-02-28 US disclosed
US-20230058134-A1 ALDOSE REDUCTASE INHIBITORS FOR THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME, ACUTE LUNG INFLAMMATION/INJURY, CARDIAC INJURY AND ANTI-VIRAL THERAPY BARCLAYS BANK PLC (GB) 2023-02-23 US disclosed
EP-4135674-A1 ALDOSE REDUCTASE INHIBITORS FOR TREATING SORBITOL DEHYDROGENASE DEFICIENCY Applied Therapeutics Inc. (US) 2023-02-22 EP disclosed
EP-4125909-A1 ALDOSE REDUCTASE INHIBITORS FOR THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME, ACUTE LUNG INFLAMMATION/INJURY, CARDIAC INJURY AND ANTI-VIRAL THERAPY Applied Therapeutics Inc. (US) 2023-02-08 EP disclosed
EP-4041219-A1 ALDOSE REDUCTASE INHIBITORS FOR TREATMENT OF PHOSPHOMANNOMUTASE 2 DEFICIENCY Applied Therapeutics, Inc. (US) 2022-08-17 EP disclosed
US-20220244263-A1 METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-08-04 US disclosed
US-20220226323-A1 ALDOSE REDUCTASE INHIBITORS FOR TREATMENT OF PHOSPHOMANNOMUTASE 2 DEFICIENCY BARCLAYS BANK PLC (GB) 2022-07-21 US disclosed
CN-114667139-A Aldose reductase inhibitors for the treatment of phosphomannomutase 2 deficiency 应用治疗公司 2022-06-24 CN disclosed
US-20220071880-A1 METHODS FOR TREATING CUTANEOUS AGING Applied Therapeutics, Inc. (US) 2022-03-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11590131-B2 Compositions and methods for treating galactosemia GLA, ALDOA, GALC KMT2A 2585/4885MEN1 3693/4885BRD4 3699/4885
US-20240238288-A1 ALDOSE REDUCTASE INHIBITORS FOR TREATING SORBITOL DEHYDROGENASE DEFICIENCY SORD, SDHA, SDHB KMT2A 2370/4885MEN1 2784/4885BRD4 4630/4885
US-20230121312-A1 ALDOSE REDUCTASE INHIBITORS FOR TREATING SORBITOL DEHYDROGENASE DEFICIENCY SORD, SDHA, SDHB KMT2A 2370/4885MEN1 2784/4885BRD4 4630/4885
US-20230372374-A1 VETERINARY PHARMACEUTICAL FORMULATIONS SLC5A2, SLC5A1, SLC2A8 KMT2A 2591/4885MEN1 3081/4885BRD4 3149/4885
US-20220226323-A1 ALDOSE REDUCTASE INHIBITORS FOR TREATMENT OF PHOSPHOMANNOMUTASE 2 DEFICIENCY PMM2, PGM2, ALDOA KMT2A 1292/4885MEN1 1744/4885BRD4 4626/4885
US-20220071880-A1 METHODS FOR TREATING CUTANEOUS AGING GLA, ADH1B, ALDH2 KMT2A 3379/4885MEN1 4840/4885BRD4 3466/4885
US-20230058134-A1 ALDOSE REDUCTASE INHIBITORS FOR THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME, ACUTE LUNG INFLAMMATION/INJURY, CARDIAC INJURY AND ANTI-VIRAL THERAPY ALDOA, AKR1B1, ACE KMT2A 2858/4885MEN1 4726/4885BRD4 3152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.