Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | FNTA | P49354 | 1/20 | 0.55 |
| ▸ | FNTB | P49356 | 1/20 | 0.55 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.53 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 7/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31172257 | 0.87 | PTPN1 (0.55) | MAOBPTPN1PARP15PARP10PARP14 | |
| SCHEMBL2987817 | 0.82 | RAB9A (0.74) | PTPN1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL25820980 | 0.80 | MAPT (0.49) | MEN1KMT2AMAPT | |
| SCHEMBL3504251 | 0.79 | FNTA (0.61) | MAOBFNTAFNTBPARP15PARP10 | |
| SCHEMBL627043 | 0.78 | ALDH1A1 (0.53) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL31703470 | 0.78 | MAOB (0.58) | MAOBPARP10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31396749 | 0.78 | NAMPT (0.57) | KMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL16407911 | 0.78 | KDM1A (0.59) | MAOBPTPN1PARP15PARP10PARP14 | |
| SCHEMBL28682913 | 0.78 | KDM1A (0.59) | MAOBPTPN1PARP15PARP10PARP14 | |
| SCHEMBL28682914 | 0.78 | KDM1A (0.59) | MAOBPTPN1PARP15PARP10PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| EP-1684762-A4 | UREA DERIVATIVES AS KINASE MODULATORS | AMBIT BIOSCIENCES CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1684762-A2 | UREA DERIVATIVES AS KINASE MODULATORS | Ambit Biosciences Corporation (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20050267182-A1 | Urea derivatives as FLT-3 modulators | AMBIT BIOSCIENCES CORPORATION | 2005-12-01 | — | — | US | disclosed |
| US-20050197371-A1 | Urea derivatives as PDGFR modulators | AMBIT BIOSCIENCES CORPORATION | 2005-09-08 | — | — | US | disclosed |
| US-20050192314-A1 | Urea derivatives as C-kit modulators | AMBIT BIOSCIENCES CORPORATION | 2005-09-01 | — | — | US | disclosed |
| US-20050165024-A1 | Urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION | 2005-07-28 | — | — | US | disclosed |
| US-20050165031-A1 | Urea derivatives as ABL modulators | AMBIT BIOSCIENCES CORPORATION | 2005-07-28 | — | — | US | disclosed |
| WO-2005048948-A2 | UREA DERIVATIVES AS KINASE MODULATORS | AMBIT BIOSCIENCES CORPORATION (US) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165024-A1 | Urea derivatives as kinase modulators | ULK2, ULK1, ULK3 | MAOB 2772/4885PTPN1 1747/4885FNTA 1784/4885 |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | MAOB 3127/4885PTPN1 706/4885FNTA 597/4885 |
| US-20050192314-A1 | Urea derivatives as C-kit modulators | KIT, PRKCH, PRKCE | MAOB 1166/4885PTPN1 2552/4885FNTA 3320/4885 |
| US-20050267182-A1 | Urea derivatives as FLT-3 modulators | FLT4, FLT1, FLT3 | MAOB 2102/4885PTPN1 1560/4885FNTA 2720/4885 |
| US-20050197371-A1 | Urea derivatives as PDGFR modulators | PDGFRA, PDGFRB, PDGFA | MAOB 3015/4885PTPN1 883/4885FNTA 1985/4885 |
| US-20050165031-A1 | Urea derivatives as ABL modulators | ABL1, ABL2, BCR | MAOB 3127/4885PTPN1 706/4885FNTA 597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.