Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 7/20 | 0.43 |
| ▸ | MMP2 | P08253 | 5/20 | 0.43 |
| ▸ | MMP3 | P08254 | 5/20 | 0.43 |
| ▸ | MMP9 | P14780 | 5/20 | 0.43 |
| ▸ | MMP8 | P22894 | 5/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 4/20 | 0.36 |
| ▸ | MMP7 | P09237 | 2/20 | 0.36 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29429485 | 0.88 | LMNA (0.47) | LMNAPOLBSMN1; SMN2MMP13MMP2 | |
| SCHEMBL2361594 | 0.87 | LMNA (0.49) | LMNAPOLBSMN1; SMN2MMP13MMP2 | |
| SCHEMBL29356156 | 0.81 | LMNA (0.46) | LMNAPOLBSMN1; SMN2MMP13MMP2 | |
| SCHEMBL7199941 | 0.81 | NPY2R (0.48) | LMNAPOLBSMN1; SMN2MMP13MMP2 | |
| SCHEMBL29850834 | 0.80 | LMNA (0.56) | LMNAPOLBSMN1; SMN2MMP13MMP2 | |
| SCHEMBL12468609 | 0.80 | SMN1; SMN2 (0.47) | LMNAPOLBSMN1; SMN2MMP13MMP2 | |
| SCHEMBL12468859 | 0.80 | SMN1; SMN2 (0.47) | LMNAPOLBSMN1; SMN2MMP13MMP2 | |
| SCHEMBL9666136 | 0.78 | SMN1; SMN2 (0.46) | LMNAPOLBSMN1; SMN2MMP13MMP2 | |
| SCHEMBL14159621 | 0.78 | SMN1; SMN2 (0.51) | LMNAPOLBSMN1; SMN2CHRM1CHRM2 | |
| SCHEMBL2345851 | 0.78 | SMN1; SMN2 (0.51) | LMNAPOLBSMN1; SMN2CHRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146785-A1 | PYRROLIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2023-08-03 | — | — | WO | disclosed |