Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12468859 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAPOLBMMP13MMP3 | |
| SCHEMBL27830884 | 0.82 | LMNA (0.51) | SMN1; SMN2LMNAPOLBMMP13MMP3 | |
| SCHEMBL15974247 | 0.81 | LMNA (0.49) | SMN1; SMN2LMNAPOLBMMP13MMP3 | |
| SCHEMBL29850834 | 0.81 | LMNA (0.56) | SMN1; SMN2LMNAPOLBMMP13MMP3 | |
| SCHEMBL2361594 | 0.81 | LMNA (0.49) | SMN1; SMN2LMNAPOLBMMP13MMP3 | |
| SCHEMBL9666136 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAPOLBMMP13MMP3 | |
| SCHEMBL30543794 | 0.80 | LMNA (0.48) | SMN1; SMN2LMNAPOLBMMP13MMP3 | |
| SCHEMBL12469109 | 0.79 | ALDH1A1 (0.47) | SMN1; SMN2LMNAPOLBMMP13MMP3 | |
| SCHEMBL29429485 | 0.78 | LMNA (0.47) | SMN1; SMN2LMNAPOLBMMP13MMP3 | |
| SCHEMBL1280145 | 0.78 | NR1H2 (0.44) | HPGDALDH1A1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627630-A1 | SEROTONIN REUPTAKE INHIBITORS | Theravance, Inc. (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051103-A1 | SEROTONIN REUPTAKE INHIBITORS | THERAVANCE, INC. (US) | 2012-04-19 | — | — | WO | disclosed |