Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3920433 | 0.86 | ATM (0.40) | NPSR1ALDH1A1CCR5KMT2AMEN1 | |
| SCHEMBL3917759 | 0.83 | NPSR1 (0.39) | NPSR1ALDH1A1LMNASMN1; SMN2CCR5 | |
| SCHEMBL2943556 | 0.82 | LMNA (0.49) | ALDH1A1LMNASMN1; SMN2CCR5KMT2A | |
| SCHEMBL4041819 | 0.81 | CCR5 (0.37) | ALDH1A1LMNASMN1; SMN2CCR5KMT2A | |
| SCHEMBL2941205 | 0.80 | MEN1 (0.44) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2932813 | 0.79 | MEN1 (0.43) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4038265 | 0.79 | KDM4E (0.37) | LMNACCR5KMT2AMEN1GAA | |
| SCHEMBL2938912 | 0.76 | CYP3A4 (0.42) | ALDH1A1LMNASMN1; SMN2CCR5KMT2A | |
| SCHEMBL2941530 | 0.75 | HPGD (0.43) | NPSR1ALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL2934783 | 0.74 | CCR5 (0.40) | ALDH1A1LMNASMN1; SMN2CCR5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |