Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3597086 | 1.00 | KMT2A (0.44) | KMT2APRKDCMRGPRX4ALDH1A1MAPT | |
| SCHEMBL3585863 | 0.91 | PDE5A (0.46) | KMT2AALDH1A1MAPTGAAALOX15 | |
| SCHEMBL14390907 | 0.88 | KMT2A (0.46) | KMT2APRKDCMRGPRX4ALDH1A1MAPT | |
| SCHEMBL22215627 | 0.84 | PDE5A (0.39) | KMT2APRKDCALDH1A1MAPTGAA | |
| SCHEMBL3589518 | 0.81 | ADORA2A (0.39) | KMT2AALDH1A1MAPTGAAALOX15 | |
| SCHEMBL3592516 | 0.80 | ALDH1A1 (0.46) | KMT2AALDH1A1MAPTGAAADORA2A | |
| SCHEMBL3597920 | 0.79 | ALDH1A1 (0.55) | KMT2AALDH1A1MAPTGAAALOX15 | |
| SCHEMBL14391023 | 0.78 | KDM4E (0.40) | KMT2AALDH1A1MAPTGAAALOX15 | |
| SCHEMBL3582806 | 0.78 | TSHR (0.43) | KMT2AALDH1A1MAPTGAAALOX15 | |
| SCHEMBL3588104 | 0.77 | ADORA2A (0.38) | KMT2AALDH1A1MAPTGAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | DREXEL UNIVERSITY | 2022-03-31 | — | — | US | claimed |
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | DREXEL UNIVERSITY | 2022-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | SQOR, QSOX1, KEAP1 | KMT2A 677/4885PRKDC 4882/4885MRGPRX4 2494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.