Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3597086 | 0.91 | KMT2A (0.44) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL29442273 | 0.91 | KMT2A (0.44) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL22215627 | 0.89 | PDE5A (0.39) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL14391023 | 0.87 | KDM4E (0.40) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL13545988 | 0.83 | PDE5A (0.46) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL3580550 | 0.80 | PDE5A (0.45) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL13545981 | 0.79 | PDE5A (0.47) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL3591628 | 0.79 | ADORA2A (0.56) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL3580685 | 0.79 | PDE5A (0.48) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL14390907 | 0.78 | KMT2A (0.46) | KDM4EHPGDTDP1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | DREXEL UNIVERSITY | 2022-03-31 | — | — | US | claimed |
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | DREXEL UNIVERSITY | 2022-03-31 | — | — | US | disclosed |
| US-20100009973-A1 | Integrase Inhibitors 3 | AVEXA LIMITED (AU) | 2010-01-14 | — | — | US | disclosed |
| US-20100009973-A1 | Integrase Inhibitors 3 | AVEXA LIMITED (AU) | 2010-01-14 | — | — | US | disclosed |
| US-20100009973-A1 | Integrase Inhibitors 3 | AVEXA LIMITED (AU) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | SQOR, QSOX1, KEAP1 | PDE5A 503/4885PDE1A 3231/4885PDE1B 3359/4885 |
| US-20100009973-A1 | Integrase Inhibitors 3 | TYMP, IMPDH1, IMPDH2 | PDE5A 531/4885PDE1A 2156/4885PDE1B 2475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.