Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.42 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23777331 | 0.85 | SLC6A11 (0.47) | SMN1; SMN2NPC1RAB9AALDH1A1ACHE | |
| SCHEMBL3700787 | 0.85 | L3MBTL1 (0.47) | LMNASMN1; SMN2L3MBTL1MAPTNPC1 | |
| SCHEMBL3691998 | 0.81 | TGM2 (0.45) | LMNASMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL3689628 | 0.81 | TGM2 (0.45) | LMNASMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL29450733 | 0.80 | L3MBTL1 (0.41) | L3MBTL1NPC1RAB9AACHESLC6A1 | |
| SCHEMBL29450732 | 0.80 | L3MBTL1 (0.41) | L3MBTL1NPC1RAB9AACHESLC6A1 | |
| SCHEMBL30823376 | 0.80 | SMN1; SMN2 (0.97) | LMNASMN1; SMN2L3MBTL1MAPTGAA | |
| SCHEMBL23777354 | 0.80 | TP53 (0.47) | LMNANPC1RAB9AGAATAAR1 | |
| SCHEMBL3097108 | 0.79 | HTT (0.62) | LMNASMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL18594580 | 0.79 | SMN1; SMN2 (0.83) | LMNASMN1; SMN2L3MBTL1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220062323-A1 | BIVALENT TARGETED CONJUGATES | ARBUTUS BIOPHARMA CORPORATION (CA) | 2022-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220062323-A1 | BIVALENT TARGETED CONJUGATES | ERBB2, PCNA, MRE11 | LMNA 1950/4885SMN1; SMN2 1422/4885L3MBTL1 623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.