Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 6/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.33 |
| ▸ | ABL1 | P00519 | 4/20 | 0.33 |
| ▸ | EGFR | P00533 | 4/20 | 0.33 |
| ▸ | HCK | P08631 | 4/20 | 0.33 |
| ▸ | SRC | P12931 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953126 | 0.85 | ADORA2A (0.47) | ADORA3ADORA2AADORA1ADORA2BRPS6KB1 | |
| SCHEMBL2948983 | 0.65 | ADORA2A (0.37) | MTORADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL2030108 | 0.64 | ADORA2A (0.35) | RETADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL21311236 | 0.64 | RPS6KB1 (0.50) | MTORRPS6KB1ROCK1PIK3CAPIK3CD | |
| SCHEMBL23929340 | 0.63 | CYP1A2 (0.39) | MTORAKT1PIK3CAJAK2JAK1 | |
| SCHEMBL29987032 | 0.63 | CYP1A2 (0.39) | MTORAKT1PIK3CAJAK2JAK1 | |
| SCHEMBL14247586 | 0.63 | CCNC (0.43) | MTORROCK1PIK3CAPIK3CD | |
| SCHEMBL25269666 | 0.62 | MTOR (0.44) | RETMTORPIK3CAPIK3CDJAK2 | |
| SCHEMBL28495220 | 0.62 | ADORA2A (0.46) | ADORA3ADORA2AADORA1ADORA2BRPS6KB1 | |
| SCHEMBL16084167 | 0.61 | CYP11B2 (0.43) | MTORAKT1PIK3CAJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |