Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.44 |
| ▸ | PRKACA | P17612 | 6/20 | 0.41 |
| ▸ | GSK3B | P49841 | 6/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.41 |
| ▸ | PI4KA | P42356 | 3/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945103 | 0.85 | RET (0.36) | ADORA2AADORA3ADORA1ADORA2BPRKACA | |
| SCHEMBL2948983 | 0.67 | ADORA2A (0.37) | ADORA2AADORA3ADORA1ADORA2BGSK3B | |
| SCHEMBL8978388 | 0.66 | ALDH1A1 (0.37) | ADORA2AADORA3ADORA1HCAR1KDM4E | |
| SCHEMBL2030108 | 0.66 | ADORA2A (0.35) | ADORA2AADORA3ADORA1ADORA2BPRKACA | |
| Hydrochloric Acid SCHEMBL27338760 | 0.65 | ALDH1A1 (0.37) | ADORA2AADORA3ADORA1HCAR1KDM4E | |
| SCHEMBL31061173 | 0.64 | ADORA2A (1.00) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL28495220 | 0.64 | ADORA2A (0.46) | ADORA2AADORA3ADORA1ADORA2BPRKACA | |
| Hydrochloric Acid SCHEMBL9377636 | 0.62 | ALDH1A1 (0.46) | HCAR1KDM4EALDH1A1MAPTGFER | |
| SCHEMBL5778683 | 0.61 | PDE4B (0.54) | PRKACAGSK3BROCK1RPS6KB1HCAR1 | |
| SCHEMBL5732265 | 0.61 | ADORA2A (0.69) | ADORA2AADORA3ADORA1ADORA2BPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | VHL, TP53, ASAH2 | ADORA2A 1259/4885ADORA3 1744/4885ADORA1 2771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.