Strictosidine

Strictosidine

SCHEMBL29456742

C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@H]1C[C@@H]1NCCc2c1[nH]c1ccccc21

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ HTR1A P08908 2/20 0.56
▸ ACHE P22303 1/20 0.52
▸ POLB P06746 1/20 0.44
▸ CTDSP1 Q9GZU7 1/20 0.44
▸ STAT3 P40763 12/20 0.43
▸ MEN1 O00255 1/20 0.42
▸ MAPT P10636 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ PTPN1 P18031 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Strictosidine SCHEMBL29456822 1.00 HTR1A (0.56) HTR1AACHEPOLBCTDSP1STAT3
Strictosidine SCHEMBL8322946 1.00 HTR1A (0.56) HTR1AACHEPOLBCTDSP1STAT3
Strictosidinic Acid SCHEMBL4729136 0.92 HTR1A (0.48) HTR1AACHEPOLBCTDSP1STAT3
SCHEMBL22919319 0.90 HTR1A (0.47) HTR1AACHEMEN1KMT2A
SCHEMBL19353678 0.84 CYP2D6 (0.44) MEN1KMT2A
SCHEMBL4097773 0.80 DRD2 (0.48) POLBCTDSP1STAT3MEN1MAPT
SCHEMBL3205755 0.80 DRD2 (0.48) POLBCTDSP1STAT3MEN1MAPT
SCHEMBL2978568 0.79 HTR1A (0.72) HTR1ASTAT3MAPT
Secologanin SCHEMBL22658018 0.77 HTR1A (0.68) HTR1AACHESTAT3MEN1MAPT
SCHEMBL30004407 0.77 HTR1A (0.46) HTR1AACHEPOLBCTDSP1STAT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122056909-A Application of catharanthin lactam in preparation of medicine for treating periodontitis 海南森祺制药有限公司 2026-05-19 — — CN claimed
CN-119464419-A Epoxide amide synthetase, method for synthesizing epoxide amide and application 中国科学院分子植物科学卓越创新中心 2025-02-18 — — CN claimed
CN-117448396-A New method for synthesizing isocatharanthin and application thereof 中国科学院分子植物科学卓越创新中心 2024-01-26 — — CN claimed
CN-122056909-A Application of catharanthin lactam in preparation of medicine for treating periodontitis 海南森祺制药有限公司 2026-05-19 — — CN disclosed
CN-120965781-A Method for green and efficient extraction of isocatharanthin from Ardisia japonica 中国医学科学院药用植物研究所海南分所 2025-11-18 — — CN disclosed
CN-120888516-A Functional identification and application of alpha-ketoglutarate-dependent dioxygenase involved in camptothecin biosynthesis 中国医学科学院药用植物研究所 2025-11-04 — — CN disclosed
US-20250179544-A1 PRODUCTION OF CORYNANTHE-TYPE MONOTERPENE INDOLE ALKALOID COMPOUNDS IN A HETEROLOGOUS HOST CB Therapeutics (US) 2025-06-05 — — US disclosed
US-12319948-B2 Pterin-dependent biocatalysts and uses thereof GEORGIA TECH RESEARCH CORPORATION (US) 2025-06-03 — — US disclosed
EP-4526426-A2 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS Danmarks Tekniske Universitet (DK) 2025-03-26 — — EP disclosed
CN-119464419-A Epoxide amide synthetase, method for synthesizing epoxide amide and application 中国科学院分子植物科学卓越创新中心 2025-02-18 — — CN disclosed
CN-119464419-A Epoxide amide synthetase, method for synthesizing epoxide amide and application 中国科学院分子植物科学卓越创新中心 2025-02-18 — — CN disclosed
CN-117448396-A New method for synthesizing isocatharanthin and application thereof 中国科学院分子植物科学卓越创新中心 2024-01-26 — — CN disclosed
WO-2023222879-A2 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS DANMARKS TEKNISKE UNIVERSITET (DK) 2023-11-23 — — WO disclosed
CN-116832092-A Alcohol precipitation process of nauclea officinalis extract powder 合荣嘉医药科技(南通)有限公司 2023-10-03 — — CN disclosed
CN-114288342-B Application of lignum naucleae extract in preparation of medicines for inhibiting increase of lung permeability and/or lung injury 海南医学院 2023-08-11 — — CN disclosed
CN-115873870-A Gene, carrier, microsomal protein and application of CYP71BE epoxidase in camptotheca acuminata 四川农业大学 2023-03-31 — — CN disclosed
CN-115656357-A Method for simultaneously detecting 10 active ingredient contents in nauclea officinalis leaves 中国医学科学院药用植物研究所海南分所 2023-01-31 — — CN disclosed
US-20220228180-A1 Methods for production of strictosidine aglycone and monoterpenoid indole alkaloids DANMARKS TEKNISKE UNIVERSITET (DK) 2022-07-21 — — US disclosed
WO-2022106638-A1 METHODS FOR PRODUCTION OF CIS-TRANS-NEPETALACTOL AND IRIDOIDS DANMARKS TEKNISKE UNIVERSITET (DK) 2022-05-27 — — WO disclosed
US-20220090154-A1 PTERIN-DEPENDENT BIOCATALYSTS AND USES THEREOF GEORGIA TECH RESEARCH CORPORATION 2022-03-24 — — US disclosed
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