Apidaecin Ia

Apidaecin Ia

SCHEMBL29458103

CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CN)C(C)C)[C@@H](C)CC)C(=O)O

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ NPY2R P49146 8/20 0.63
▸ NPY4R P50391 8/20 0.63
▸ NPY5R Q15761 8/20 0.63
▸ NPY1R P25929 6/20 0.63
▸ TFPI P10646 5/20 0.60
▸ AGTR1 P30556 4/20 0.60
▸ AGTR2 P50052 2/20 0.60
▸ RAMP3 O60896 1/20 0.56
▸ CALCR P30988 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Apidaecin SCHEMBL29380656 0.96 NPY4R (0.67) NPY2RNPY4RNPY5RNPY1RTFPI
SCHEMBL29458102 0.93 NPY4R (0.62) NPY2RNPY4RNPY5RNPY1RTFPI
Apidaecin Ia SCHEMBL31694517 0.92 F2 (0.58) NPY2RNPY4RNPY5RNPY1RRAMP3
SCHEMBL18872896 0.88 AGTR1 (0.68) NPY2RNPY4RNPY5RNPY1RAGTR1
SCHEMBL29874441 0.88 NPY2R (0.69) NPY2RNPY4RNPY5RNPY1RTFPI
SCHEMBL18872894 0.87 AGTR1 (0.68) NPY2RNPY4RNPY5RNPY1RAGTR1
Drosocin SCHEMBL29539177 0.86 NPY2R (0.66) NPY2RNPY4RNPY5RNPY1RTFPI
SCHEMBL29702111 0.84 F2 (0.61) NPY2RNPY4RNPY5RNPY1R
SCHEMBL38662565 0.84 NPY2R (0.63) NPY2RNPY4RNPY5RNPY1RTFPI
Trv-120027 SCHEMBL29382211 0.84 AGTR1 (0.73) NPY2RNPY4RNPY5RNPY1RAGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025227105-A1 CLEAVABLE LINKERS WITH TUNABLE HALF-LIVES UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2025-10-30 — — WO disclosed
US-RE50618-E1 Anionic-core composition for delivery of therapeutic agents, and methods of making and using the same PHARMAIN CORPORATION (US) 2025-10-07 — — US disclosed
US-20250256007-A1 GELMA POLYMER COMPOSITIONS COMPRISING CELLS GELMEDIX INC (US) 2025-08-14 — — US disclosed
WO-2025085609-A1 ACRYLATED GELATIN POLYMER COMPOSITIONS COMPRISING CELLS GELMEDIX, INC. (US) 2025-04-24 — — WO disclosed
EP-4511075-A1 GELMA POLYMER COMPOSITIONS COMPRISING CELLS Gelmedix, Inc. (US) 2025-02-26 — — EP disclosed
US-20240398958-A1 GELMA POLYMER COMPOSITIONS AND USES THEREOF GELMEDIX INC (US) 2024-12-05 — — US disclosed
US-20240374792-A1 GELMA POLYMER COMPOSITIONS AND USES THEREOF GELMEDIX INC (US) 2024-11-14 — — US disclosed
US-20240269293-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF OD THERAPEUTICS LIMITED (CN) 2024-08-15 — — US disclosed
EP-4401802-A1 GELMA POLYMER COMPOSITIONS AND USES THEREOF Gelmedix, Inc. (US) 2024-07-24 — — EP disclosed
CN-118215511-A GELMA polymer compositions and uses thereof 盖尔梅迪克斯公司 2024-06-18 — — CN disclosed
EP-4313154-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF OD Therapeutics Limited (HK) 2024-02-07 — — EP disclosed
WO-2023205265-A1 GELMA POLYMER COMPOSITIONS COMPRISING CELLS GELMEDIX, INC. (US) 2023-10-26 — — WO disclosed
WO-2023044389-A1 GELMA POLYMER COMPOSITIONS COMPRISING CORTICOSTEROIDS GELMEDIX, INC. (US) 2023-03-23 — — WO disclosed
WO-2023044385-A1 GELMA POLYMER COMPOSITIONS AND USES THEREOF GELMEDIX, INC. (US) 2023-03-23 — — WO disclosed
US-20220401561-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF AJ SCIENCES (YIXING) CO., LTD (CN) 2022-12-22 — — US disclosed
US-11473104-B2 Engineered phagemids MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2022-10-18 — — US disclosed
WO-2022212362-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF BEIJING XUANYI PHARMASCIENCES CO., LTD. (CN) 2022-10-06 — — WO disclosed
US-20220288273-A1 OSTEOINDUCTIVE MODIFIED GELATIN HYDROGELS AND METHODS OF MAKING AND USING THE SAME THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-09-15 — — US disclosed
EP-4037715-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF Beijing Xuanyi Pharmasciences Co., Ltd. (CN) 2022-08-10 — — EP disclosed
WO-2022076505-A1 GELMA POLYMER COMPOSITIONS AND USES THEREOF GELMEDIX, INC. (US) 2022-04-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240269293-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF CD44, MACROD1, MSN NPY2R 4275/4885NPY4R 4231/4885NPY5R 4217/4885
US-20220401561-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF CD44, SSB, DNPEP NPY2R 4224/4885NPY4R 4239/4885NPY5R 4145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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