SCHEMBL29874441

SCHEMBL29874441

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CN)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)[C@@H](C)CC

nearest known ligand 0.69

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ NPY2R P49146 8/20 0.69
▸ NPY4R P50391 8/20 0.69
▸ NPY5R Q15761 8/20 0.69
▸ NPY1R P25929 6/20 0.69
▸ TFPI P10646 7/20 0.67
▸ RAMP3 O60896 3/20 0.65
▸ CALCR P30988 3/20 0.65
▸ AGTR1 P30556 1/20 0.58
▸ AGTR2 P50052 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Apidaecin SCHEMBL29380656 0.90 NPY4R (0.67) NPY2RNPY4RNPY5RNPY1RTFPI
SCHEMBL29360416 0.89 NPY2R (0.66) NPY2RNPY4RNPY5RNPY1RTFPI
Apidaecin Ia SCHEMBL29458103 0.88 NPY2R (0.63) NPY2RNPY4RNPY5RNPY1RTFPI
SCHEMBL29458102 0.87 NPY4R (0.62) NPY2RNPY4RNPY5RNPY1RTFPI
Isracidin SCHEMBL29668326 0.85 NPY2R (0.70) NPY2RNPY4RNPY5RNPY1RTFPI
SCHEMBL32930844 0.85 AGTR1 (0.70) NPY2RNPY4RNPY5RNPY1RTFPI
SCHEMBL29509548 0.84 TFPI (0.65) NPY2RNPY4RNPY5RNPY1RTFPI
Talfirastide SCHEMBL29367137 0.84 AGTR2 (0.73) NPY2RNPY4RNPY5RNPY1RAGTR1
SCHEMBL29359777 0.84 NPY2R (0.63) NPY2RNPY4RNPY5RNPY1RTFPI
SCHEMBL30495738 0.84 NPY2R (0.61) NPY2RNPY4RNPY5RNPY1RTFPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260097149-A1 CELL FREE VASCULAR GRAFTS AND GRAFT MATERIALS FOR CELLULAR RECRUITMENT UNIV NEW YORK STATE RES FOUND (US) 2026-04-09 — — US disclosed
US-20260055150-A1 GRAIL-1 PEPTIDE PRODUCTS AND METHODS UNIV MICHIGAN (US) 2026-02-26 — — US disclosed
EP-4565333-A2 GRAIL-1 PEPTIDE PRODUCTS AND METHODS Regents of the University of Michigan (US) 2025-06-11 — — EP disclosed
US-12310975-B2 Modulators of BCL6 proteolysis and associated methods of use ARVINAS OPERATIONS, INC. (US) 2025-05-27 — — US disclosed
CN-119019369-A Bifunctional molecules comprising an E3 ubiquitin ligase binding moiety linked to a BCL6 targeting moiety 阿尔维纳斯运营股份有限公司 2024-11-26 — — CN disclosed
US-20240325547-A1 MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2024-10-03 — — US disclosed
CN-115397821-B Bifunctional molecules comprising an E3 ubiquitin ligase binding moiety linked to a BCL6 targeting moiety 阿尔维纳斯运营股份有限公司 2024-09-03 — — CN disclosed
CN-118388454-A Modulators of BCL6 proteolysis and related methods of use 阿尔维纳斯运营股份有限公司 2024-07-26 — — CN disclosed
CN-110520729-B Methods for generating and screening isolated peptide libraries 南安普顿大学 2024-05-28 — — CN disclosed
US-11986532-B2 Modulators of BCL6 proteolysis and associated methods of use ARVINAS OPERATIONS, INC. (US) 2024-05-21 — — US disclosed
CN-117717617-A Amphiphilic polyoxazoline vaccine carrier, preparation method and application thereof 中国科学院长春应用化学研究所 2024-03-19 — — CN disclosed
EP-4323352-A1 MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE Arvinas Operations, Inc. (US) 2024-02-21 — — EP disclosed
WO-2024031003-A2 GRAIL-1 PEPTIDE PRODUCTS AND METHODS REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2024-02-08 — — WO disclosed
WO-2024026035-A2 PEPTIDE TAGS FOR PHAGE IMAGING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-02-01 — — WO disclosed
WO-2023250519-A1 CELL FREE VASCULAR GRAFTS AND GRAFT MATERIALS FOR CELLULAR RECRUITMENT THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2023-12-28 — — WO disclosed
US-20220395576-A1 MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2022-12-15 — — US disclosed
US-20220323457-A1 MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2022-10-13 — — US disclosed
EP-4045496-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY Arvinas Operations, Inc. (US) 2022-08-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260055150-A1 GRAIL-1 PEPTIDE PRODUCTS AND METHODS TP53, TP53BP1, DDIT3 NPY2R 1365/4885NPY4R 1094/4885NPY5R 1544/4885
US-12310975-B2 Modulators of BCL6 proteolysis and associated methods of use BCL6, BCL6B, BCL3 NPY2R 4228/4885NPY4R 4527/4885NPY5R 4568/4885
US-11986532-B2 Modulators of BCL6 proteolysis and associated methods of use BCL6, BCL6B, BCL3 NPY2R 4201/4885NPY4R 4154/4885NPY5R 4185/4885
US-20220323457-A1 MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE BCL6, BCL6B, BCL3 NPY2R 4228/4885NPY4R 4527/4885NPY5R 4568/4885
US-20260097149-A1 CELL FREE VASCULAR GRAFTS AND GRAFT MATERIALS FOR CELLULAR RECRUITMENT HCLS1, ADM2, LY96 NPY2R 3284/4885NPY4R 3845/4885NPY5R 3576/4885
US-20220395576-A1 MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE BCL6, BCL6B, BCL3 NPY2R 4201/4885NPY4R 4154/4885NPY5R 4185/4885
US-20240325547-A1 MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE BCL6, BCL6B, BCL3 NPY2R 4201/4885NPY4R 4154/4885NPY5R 4185/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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