Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.38 |
| ▸ | LGMN | Q99538 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2952950 | 0.91 | DHFR (0.43) | DHFRTTK | |
| SCHEMBL2951937 | 0.85 | DHFR (0.45) | DHFRCDK1CDK2CCNB1CCNE1 | |
| SCHEMBL2953607 | 0.85 | TLR7 (0.44) | CDK1CDK2CCNB1CCNE1SMN1; SMN2 | |
| SCHEMBL2953119 | 0.82 | TTK (0.43) | TTK | |
| SCHEMBL2946373 | 0.81 | DHFR (0.43) | DHFRCDK1CDK2CCNB1CCNE1 | |
| SCHEMBL2954051 | 0.81 | DHFR (0.44) | DHFRMAPTALDH1A1USP2ALOX15 | |
| SCHEMBL30399128 | 0.80 | FYN (0.41) | DHFRMAPTRECQLMAPK1GAA | |
| SCHEMBL2952940 | 0.79 | SMPD3 (0.41) | TTK | |
| SCHEMBL2953492 | 0.78 | TTK (0.47) | ALDH1A1PIK3CBTTK | |
| SCHEMBL2948890 | 0.77 | TTK (0.45) | DHFRTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |