Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ILK | Q13418 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2955288 | 0.86 | TLR7 (0.42) | TLR7PIK3CAPTPN1ILKCDK1 | |
| SCHEMBL2946049 | 0.85 | DHFR (0.42) | SMN1; SMN2ALDH1A1CDK1CCNB1CCNE1 | |
| SCHEMBL2952950 | 0.77 | DHFR (0.43) | PIK3CAKMT2AMEN1PDE2A | |
| SCHEMBL2950165 | 0.75 | TLR7 (0.41) | TLR7PTPN1ILKCDK1CCNB1 | |
| SCHEMBL2953601 | 0.75 | PARP1 (0.42) | TLR7KMT2AMEN1NPC1TP53 | |
| SCHEMBL2952316 | 0.74 | NPC1 (0.51) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4764968 | 0.73 | HTT (0.52) | KMT2AMEN1NPC1TP53HPGD | |
| SCHEMBL2951937 | 0.73 | DHFR (0.45) | PIK3CAKMT2AMEN1NPC1TP53 | |
| SCHEMBL1748554 | 0.72 | SSTR5 (0.47) | PIK3CA | |
| SCHEMBL2946209 | 0.71 | TLR8 (0.37) | PTPN1CDK1CCNB1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |