Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | SIK1 | P57059 | 1/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.40 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 3/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946049 | 0.91 | DHFR (0.42) | DHFRTTK | |
| SCHEMBL2953119 | 0.91 | TTK (0.43) | INSRALKTTKFLT3 | |
| SCHEMBL2954051 | 0.90 | DHFR (0.44) | DHFRHSP90AA1HSP90AB1 | |
| SCHEMBL30399128 | 0.89 | FYN (0.41) | DHFRFYNHSP90AA1HSP90AB1FLT3 | |
| SCHEMBL2952940 | 0.87 | SMPD3 (0.41) | INSRALKTTK | |
| SCHEMBL2951937 | 0.86 | DHFR (0.45) | DHFRPIK3CAMEN1KMT2AMTOR | |
| SCHEMBL2953492 | 0.84 | TTK (0.47) | ALKPIK3CAMTORTTK | |
| SCHEMBL2948890 | 0.83 | TTK (0.45) | DHFRINSRALKPIK3CATTK | |
| SCHEMBL2953676 | 0.82 | EGFR (0.39) | DHFRALKFYNFLT3 | |
| SCHEMBL2946373 | 0.82 | DHFR (0.43) | DHFRPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |
| CN-116284001-A | DCLK1 inhibitor, preparation method, pharmaceutical composition and application | 中国药科大学 | 2023-06-23 | — | — | CN | disclosed |