Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2952950 | 0.83 | DHFR (0.43) | TTKPIK3CAHSP90AA1HSP90AB1DHFR | |
| SCHEMBL2953119 | 0.81 | TTK (0.43) | TTKACVR1INSRIGF1RALK | |
| SCHEMBL30399128 | 0.81 | FYN (0.41) | HSP90AA1HSP90AB1DHFR | |
| SCHEMBL2954051 | 0.80 | DHFR (0.44) | HSP90AA1HSP90AB1DHFR | |
| SCHEMBL2950126 | 0.78 | TTK (0.42) | TTKHTR7HSP90AA1HSP90AB1DHFR | |
| SCHEMBL2952940 | 0.78 | SMPD3 (0.41) | TTKINSRIGF1RALK | |
| SCHEMBL3034636 | 0.77 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1INSRIGF1RALK | |
| SCHEMBL2946049 | 0.77 | DHFR (0.42) | TTKDHFR | |
| SCHEMBL2953492 | 0.76 | TTK (0.47) | TTKPIK3CAALK | |
| SCHEMBL2953676 | 0.75 | EGFR (0.39) | DHFRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |