Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 8/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 7/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031161 | 0.84 | HSD17B1 (0.52) | HSD17B1HSD17B2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL4190376 | 0.82 | ABL1 (0.50) | ABL1OPRM1KCNH2FYN | |
| SCHEMBL29431754 | 0.80 | CYP11B1 (0.57) | CYP11B1CYP11B2HSD17B1ABL1HSD17B2 | |
| SCHEMBL1029424 | 0.79 | HSD17B1 (0.61) | HSD17B1ABL1HSD17B2CYP3A4CYP2C9 | |
| SCHEMBL4191452 | 0.77 | FYN (0.55) | CYP11B1CYP11B2CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL31418108 | 0.76 | CYP11B2 (0.49) | CYP11B1CYP11B2HSD17B1HSD17B2CYP3A4 | |
| SCHEMBL1119422 | 0.76 | CYP11B1 (0.50) | CYP11B1CYP11B2ABL1NPY5RKCNH2 | |
| SCHEMBL29320206 | 0.76 | AURKA (0.49) | ABL1NPY5RKCNH2DYRK1A | |
| SCHEMBL2089768 | 0.75 | HSD17B1 (0.55) | HSD17B1ABL1HSD17B2CYP3A4CYP2C9 | |
| SCHEMBL12110244 | 0.75 | CYP11B1 (0.59) | CYP11B1CYP11B2HSD17B1ABL1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612397-B2 | Methods and compositions for modulating splicing | SKYHAWK THERAPEUTICS, INC. (US) | 2026-04-28 | — | — | US | disclosed |
| US-20230027684-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2023-01-26 | — | — | US | disclosed |
| US-20230008867-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2023-01-12 | — | — | US | disclosed |
| US-20220048902-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2022-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230008867-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | RBM17, SF3B1, SNRPA1 | CYP11B1 2326/4885CYP11B2 2936/4885HSD17B1 2388/4885 |
| US-12612397-B2 | Methods and compositions for modulating splicing | SF3B1, SF3B2, SF1 | CYP11B1 845/4885CYP11B2 1276/4885HSD17B1 561/4885 |
| US-20230027684-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | RBM17, SF3B1, SF3B5 | CYP11B1 2186/4885CYP11B2 2820/4885HSD17B1 2342/4885 |
| US-20220048902-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | RBM17, SF3B1, SF3B5 | CYP11B1 2186/4885CYP11B2 2820/4885HSD17B1 2342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.