Remimazolam

Remimazolam

SCHEMBL29463199

COC(=O)CC[C@@H]1N=C(c2ccccn2)c2cc(Br)ccc2-n2c(C)cnc21.O=S(=O)(O)c1ccccc1

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ

The experimentally established mechanism targets of Remimazolam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GABRA1 known ✓ P14867 1/20 0.38
GABRA5 known ✓ P31644 1/20 0.38
GABRA3 known ✓ P34903 1/20 0.38
GABRA2 known ✓ P47869 1/20 0.38
GABRB2 known ✓ P47870 1/20 0.38
BRD4 O60885 3/20 0.34
PKM P14618 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TP53 P04637 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
ALOX15 P16050 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Remimazolam SCHEMBL30237991 1.00 GABRA1 (0.38) GABRA1GABRA5GABRA3GABRA2GABRB2
Remimazolam SCHEMBL825168 1.00 GABRA1 (0.38) GABRA1GABRA5GABRA3GABRA2GABRB2
Remimazolam SCHEMBL30788432 1.00 GABRA1 (0.38) GABRA1GABRA5GABRA3GABRA2GABRB2
Remimazolam SCHEMBL1539505 1.00 GABRA1 (0.38) GABRA1GABRA5GABRA3GABRA2GABRB2
Remimazolam SCHEMBL29379706 0.96 GABRA1 (0.37) GABRA1GABRA5GABRA3GABRA2GABRB2
Remimazolam SCHEMBL23735014 0.93 GABRA1 (0.42) GABRA1GABRA5GABRA3GABRA2GABRB2
Remimazolam SCHEMBL29379415 0.93 GABRA1 (0.42) GABRA1GABRA5GABRA3GABRA2GABRB2
Remimazolam SCHEMBL846435 0.93 GABRA1 (0.42) GABRA1GABRA5GABRA3GABRA2GABRB2
Remimazolam SCHEMBL29579211 0.93 GABRA1 (0.42) GABRA1GABRA5GABRA3GABRA2GABRB2
SCHEMBL25310982 0.93 GABRA1 (0.40) GABRA1GABRA5GABRA3GABRA2GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4717696-A1 METHOD FOR PREPARING REMIMAZOLAM BESYLATE WITH HIGH EFFICIENCY Hana Pharm. Co. Ltd. (KR) 2026-04-01 EP claimed
US-12331053-B2 Method for obtaining amorphous remimazolam besylate MOEHS IBERICA, S.L. (ES) 2025-06-17 US claimed
EP-4556068-A2 ORALLY INHALED AND NASAL BENZODIAZEPINES Paion UK Limited (GB) 2025-05-21 EP claimed
EP-3442539-B1 ORALLY INHALED AND NASAL BENZODIAZEPINES PAION UK LTD (GB) 2025-04-09 EP claimed
WO-2025038446-A2 USE OF REMIMAZOLAM FOR PEDIATRIC SEDATION EAGLE PHARMACEUTICALS, INC. (US) 2025-02-20 WO claimed
WO-2024242468-A1 METHOD FOR PREPARING REMIMAZOLAM BESYLATE WITH HIGH EFFICIENCY 하나제약 주식회사 2024-11-28 WO claimed
US-20240282425-A1 AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS LOW GORDON KEITH (US) 2024-08-22 US claimed
WO-2023037237-A1 PROCESS FOR THE PREPARATION OF REMIMAZOLAM WAVELENGTH ENTERPRISES LTD (IL) 2023-03-16 WO claimed
US-20220402923-A1 METHOD FOR OBTAINING AMORPHOUS REMIMAZOLAM BESYLATE MOEHS IBERICA, S.L. (ES) 2022-12-22 US claimed
EP-4003995-A1 METHOD FOR OBTAINING AMORPHOUS REMIMAZOLAM BESYLATE Moehs Ibérica, S.L. (ES) 2022-06-01 EP claimed
US-12594339-B2 Lipid prodrugs of JAK inhibitors and uses thereof SEAPORT THERAPEUTICS, INC. (US) 2026-04-07 US disclosed
EP-4717696-A1 METHOD FOR PREPARING REMIMAZOLAM BESYLATE WITH HIGH EFFICIENCY Hana Pharm. Co. Ltd. (KR) 2026-04-01 EP disclosed
EP-4717696-A1 METHOD FOR PREPARING REMIMAZOLAM BESYLATE WITH HIGH EFFICIENCY Hana Pharm. Co. Ltd. (KR) 2026-04-01 EP disclosed
EP-4717696-A1 METHOD FOR PREPARING REMIMAZOLAM BESYLATE WITH HIGH EFFICIENCY Hana Pharm. Co. Ltd. (KR) 2026-04-01 EP disclosed
EP-4695257-A1 PROCESS FOR THE PREPARATION OF REMIMAZOLAM AND SALTS THEREOF Harman Finochem Limited (IN) 2026-02-18 EP disclosed
EP-4003995-A1 METHOD FOR OBTAINING AMORPHOUS REMIMAZOLAM BESYLATE Moehs Ibérica, S.L. (ES) 2022-06-01 EP disclosed
EP-4003995-A1 METHOD FOR OBTAINING AMORPHOUS REMIMAZOLAM BESYLATE Moehs Ibérica, S.L. (ES) 2022-06-01 EP disclosed
US-20220143038-A1 LIPID PRODRUGS OF MYCOPHENOLIC ACID AND USES THEREOF PURETECH LYT, INC. (US) 2022-05-12 US disclosed
US-20220125933-A1 LIPID PRODRUGS OF JAK INHIBITORS AND USES THEREOF SEAPORT THERAPEUTICS, INC. 2022-04-28 US disclosed
US-11304954-B2 Lipid prodrugs of mycophenolic acid and uses thereof PURETECH LYT, INC. (US) 2022-04-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220125933-A1 LIPID PRODRUGS OF JAK INHIBITORS AND USES THEREOF JAK1, JAK2, JAK3 GABRA1 3441/4885GABRA5 2930/4885GABRA3 3462/4885
US-11304954-B2 Lipid prodrugs of mycophenolic acid and uses thereof MALT1, CYP2B6, LIPA GABRA1 3507/4885GABRA5 2643/4885GABRA3 3551/4885
US-12331053-B2 Method for obtaining amorphous remimazolam besylate MAP2, MAG, NEFM GABRA1 102/4885GABRA5 30/4885GABRA3 39/4885
US-12594339-B2 Lipid prodrugs of JAK inhibitors and uses thereof JAK1, JAK3, JAK2 GABRA1 3433/4885GABRA5 3713/4885GABRA3 3194/4885
US-20220143038-A1 LIPID PRODRUGS OF MYCOPHENOLIC ACID AND USES THEREOF MALT1, CYP2B6, LIPA GABRA1 3507/4885GABRA5 2643/4885GABRA3 3551/4885
US-20220402923-A1 METHOD FOR OBTAINING AMORPHOUS REMIMAZOLAM BESYLATE MAP2, MAG, NEFM GABRA1 102/4885GABRA5 30/4885GABRA3 39/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.