Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Remimazolam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.38 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Remimazolam SCHEMBL30237991 | 1.00 | GABRA1 (0.38) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Remimazolam SCHEMBL29463199 | 1.00 | GABRA1 (0.38) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Remimazolam SCHEMBL30788432 | 1.00 | GABRA1 (0.38) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Remimazolam SCHEMBL1539505 | 1.00 | GABRA1 (0.38) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Remimazolam SCHEMBL29379706 | 0.96 | GABRA1 (0.37) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Remimazolam SCHEMBL23735014 | 0.93 | GABRA1 (0.42) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Remimazolam SCHEMBL29379415 | 0.93 | GABRA1 (0.42) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Remimazolam SCHEMBL846435 | 0.93 | GABRA1 (0.42) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Remimazolam SCHEMBL29579211 | 0.93 | GABRA1 (0.42) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL25310982 | 0.93 | GABRA1 (0.40) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102753525-A | Process for preparing 3-[(4s)-8-bromo-1-methyl-6-(2-pyridinyl)-4h-imidazol[1,2-a][1,4]benzodiazepine-4-yl]propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process | PAION UK LTD | 2012-10-24 | — | — | CN | disclosed |
| EP-2477967-A1 | PROCESS FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(2-PYRIDINYL)-4H-IMIDAZOL[1,2-A][1,4]BENZODIAZEPINE-4-YL]PROPIONIC ACID METHYL ESTER OR THE BENZENE SULFONATE SALT THEREOF, AND COMPOUNDS USEFUL IN THAT PROCESS | PAION UK Limited (GB) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011032692-A1 | PROCESS FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(2-PYRIDINYL)-4H-IMIDAZOL[1,2-A][1,4]BENZODIAZEPINE-4-YL]PROPIONIC ACID METHYL ESTER OR THE BENZENE SULFONATE SALT THEREOF, AND COMPOUNDS USEFUL IN THAT PROCESS | PAION UK LIMITED (GB) | 2011-03-24 | — | — | WO | disclosed |