Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.34 |
| ▸ | FASN | P49327 | 8/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19951298 | 1.00 | KIF18A (0.34) | KIF18AHSD11B1FASNARSOS1 | |
| SCHEMBL19925208 | 0.89 | KIF18A (0.36) | KIF18ASOS1RAF1BRAF | |
| SCHEMBL19951446 | 0.88 | HSD11B1 (0.35) | KIF18AHSD11B1FASNARLRRK2 | |
| SCHEMBL19951408 | 0.88 | ADRB2 (0.35) | HSD11B1FASNSLC22A12 | |
| SCHEMBL29464385 | 0.86 | SOS1 (0.39) | KIF18AARSOS1SLC22A12KHK | |
| SCHEMBL19951407 | 0.86 | SOS1 (0.39) | KIF18AARSOS1SLC22A12KHK | |
| SCHEMBL19951400 | 0.85 | SCN9A (0.38) | HSD11B1FASNSLC22A12RAF1BRAF | |
| SCHEMBL19925199 | 0.84 | KIF18A (0.36) | KIF18ASOS1RAF1BRAF | |
| SCHEMBL19925682 | 0.82 | KIF18A (0.36) | KIF18AHSD11B1SOS1LRRK2 | |
| SCHEMBL29464448 | 0.82 | KIF18A (0.36) | KIF18AHSD11B1SOS1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |