Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 5/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 4/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925682 | 1.00 | KIF18A (0.36) | KIF18ASCN9ASOS1GHSRSCN1A | |
| SCHEMBL29464385 | 0.89 | SOS1 (0.39) | KIF18ASCN9ASOS1 | |
| SCHEMBL19951407 | 0.89 | SOS1 (0.39) | KIF18ASCN9ASOS1 | |
| SCHEMBL19968847 | 0.87 | GHSR (0.38) | SCN9ASOS1GHSRSCN1ASCN8A | |
| SCHEMBL19968848 | 0.87 | KIF18A (0.37) | KIF18ASCN9ASOS1SCN1ASCN8A | |
| SCHEMBL19925199 | 0.87 | KIF18A (0.36) | KIF18ASCN9ASOS1GHSRSCN1A | |
| SCHEMBL19925208 | 0.87 | KIF18A (0.36) | KIF18ASCN9ASOS1GHSRSCN1A | |
| SCHEMBL19951371 | 0.86 | RORC (0.39) | KIF18ASCN9AGHSRSCN1ASCN8A | |
| SCHEMBL19968828 | 0.85 | CYP1A2 (0.39) | SCN9ASOS1GHSRSCN1ASCN8A | |
| SCHEMBL23770771 | 0.85 | KMO (0.33) | KIF18ASCN9AGHSRSCN1ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |