Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 2/20 | 0.31 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
| ▸ | KIF18A | Q8NI77 | 5/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925121 | 1.00 | JAK2 (0.33) | JAK2JAK1JAK3SCN9ASCN1A | |
| SCHEMBL19925244 | 0.91 | SCN9A (0.33) | JAK2JAK1JAK3SCN9ASCN1A | |
| SCHEMBL29464451 | 0.91 | SCN9A (0.33) | JAK2JAK1JAK3SCN9ASCN1A | |
| SCHEMBL19951371 | 0.90 | RORC (0.39) | SCN9ASCN1ASCN8AADORA2ARORC | |
| SCHEMBL19925193 | 0.90 | JAK2 (0.33) | JAK2JAK1JAK3SCN9AADORA2A | |
| SCHEMBL19925765 | 0.89 | WDR5 (0.33) | JAK2JAK1JAK3SCN9ASCN1A | |
| SCHEMBL19968854 | 0.88 | KIF18A (0.33) | SCN9AKIF18A | |
| SCHEMBL29464906 | 0.88 | KIF18A (0.33) | SCN9AKIF18A | |
| SCHEMBL22323141 | 0.87 | CYP3A4 (0.36) | SCN9ASCN1ASCN8AADORA2ARORC | |
| SCHEMBL24360698 | 0.84 | CYP3A4 (0.33) | SCN9ASCN1ASCN8AKIF18ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |