Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5170255 | 0.82 | NPC1 (0.34) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL11451644 | 0.65 | MAPT (0.34) | MAPTCYP1A2CYP2D6SMN1; SMN2HTT | |
| SCHEMBL29465738 | 0.63 | MAPT (0.43) | MAPTCYP1A2CYP2D6SMN1; SMN2HTT | |
| SCHEMBL1993537 | 0.62 | LMNA (0.36) | MAPTCYP1A2SMN1; SMN2HTTGAA | |
| SCHEMBL6276533 | 0.62 | LMNA (0.36) | MAPTCYP1A2SMN1; SMN2HTTTP53 | |
| SCHEMBL21690 | 0.59 | MAPT (0.66) | MAPTCYP1A2SMN1; SMN2HTTTP53 | |
| SCHEMBL9508287 | 0.59 | MAPT (0.66) | MAPTCYP1A2SMN1; SMN2HTTTP53 | |
| SCHEMBL6129248 | 0.58 | MAPT (0.45) | MAPTCYP1A2SMN1; SMN2HTTTP53 | |
| SCHEMBL9093746 | 0.58 | LMNA (0.71) | MAPTCYP1A2SMN1; SMN2HTTTP53 | |
| SCHEMBL18946315 | 0.58 | MAPT (0.40) | MAPTCYP1A2CYP2D6SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778250-A2 | NOVEL THIAZOLE INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE | Metabasis Therapeutics, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006023515-A2 | NOVEL THIAZOLE INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE | METABASIS THERAPEUTICS, INC. (US) | 2006-03-02 | — | — | WO | disclosed |