Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.53 |
| ▸ | PARP1 | P09874 | 4/20 | 0.48 |
| ▸ | TNKS | O95271 | 2/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29468829 | 0.95 | RORC (0.58) | RORCPARP1TNKSTNKS2GPR183 | |
| SCHEMBL29468738 | 0.94 | RORC (0.52) | RORCPARP1TNKSTNKS2GPR183 | |
| SCHEMBL29468687 | 0.94 | GPR183 (0.49) | RORCPARP1TNKSTNKS2GPR183 | |
| SCHEMBL14125497 | 0.86 | SIGMAR1 (0.55) | RORCCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL30620506 | 0.85 | GPR183 (0.52) | RORCGPR183CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21276348 | 0.84 | MGLL (0.53) | RORCGPR183CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20556708 | 0.82 | ERN1 (0.56) | RORCGPR183CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1426231 | 0.81 | CYP2D6 (0.64) | CYP1A2CYP3A4CYP2D6TSHRSCD5 | |
| SCHEMBL30620521 | 0.80 | RORC (0.49) | RORCGPR183CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31565342 | 0.79 | CYP3A4 (0.60) | CYP1A2CYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228761-A1 | 2-OXO-DIHYDROQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS GABA TYPE A RECEPTOR MODULATORS | University College Cardiff Consultants Limited (GB) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022079432-A1 | 2-OXO-DIHYDROQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS GABA TYPE A RECEPTOR MODULATORS | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2022-04-21 | — | — | WO | disclosed |