Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169235 | 0.76 | MAPK8 (0.54) | MAPK8HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL120846 | 0.76 | MAPK8 (0.54) | MAPK8HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL31746758 | 0.76 | MAPK8 (0.54) | MAPK8HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL30578099 | 0.76 | MAPK8 (0.54) | MAPK8HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL13131265 | 0.76 | PTPN2 (0.59) | MAPK8HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11417540 | 0.73 | MAPK8 (0.55) | MAPK8HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL25299727 | 0.72 | ADORA2A (0.53) | MAPK8HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11469700 | 0.72 | ABCG2 (0.51) | MAPK8HPGDLMNAHTTNPC1 | |
| SCHEMBL15958608 | 0.72 | HTR3E (0.53) | MAPK8HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8110850 | 0.72 | MAPK8 (0.64) | MAPK8HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4229452-A | Treatment of inflammatory disorders with 4-trifluoromethylimidazo[1,2-a]quinoxaline | WESTWOOD PHARMACEUTICALS, INC. | 1980-10-21 | — | — | US | claimed |
| US-4200750-A | ANTIINFLAMMATORY AGENTS, FUNGICIDES, ANTIBODY INHIBITORS | WESTWOOD PHARMACEUTICALS INC. (US) | 1980-04-29 | — | — | US | claimed |
| US-7750024-B2 | Remedy for glioblastoma | ASTELLAS PHARMA INC. (JP) | 2010-07-06 | — | — | US | disclosed |
| US-20050165009-A1 | Remedy for glioblastoma | ASTELLAS PHARMA INC. (JP) | 2005-07-28 | — | — | US | disclosed |
| US-4229452-A | Treatment of inflammatory disorders with 4-trifluoromethylimidazo[1,2-a]quinoxaline | WESTWOOD PHARMACEUTICALS, INC. | 1980-10-21 | — | — | US | disclosed |
| US-4229452-A | Treatment of inflammatory disorders with 4-trifluoromethylimidazo[1,2-a]quinoxaline | WESTWOOD PHARMACEUTICALS, INC. | 1980-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165009-A1 | Remedy for glioblastoma | GRM2, GRM1, GRM3 | MAPK8 2449/4885HTR3E 2291/4885HTR3B 2325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.