SCHEMBL29478310

CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cc(Br)c3c(N)ncnc32)[C@H](F)[C@@H]1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.51

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	ADK	P55263	5/20	0.51

▸	PRMT5	O14744	11/20	0.49

▸	METTL3	Q86U44	10/20	0.49

▸	DOT1L	Q8TEK3	2/20	0.41

▸	PRMT3	O60678	1/20	0.41

▸	DNMT1	P26358	1/20	0.41

▸	NNMT	P40261	1/20	0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29478322	0.90	ADK (0.54)	ADKPRMT5METTL3DOT1L
SCHEMBL29478319	0.84	ADK (0.47)	ADKPRMT5METTL3
SCHEMBL29478317	0.83	ADK (0.47)	ADKPRMT5METTL3
SCHEMBL24377429	0.82	NT5E (0.49)	DOT1L
SCHEMBL21393132	0.82	NT5E (0.49)	DOT1L
SCHEMBL21384830	0.82	NT5E (0.49)	DOT1L
SCHEMBL24313824	0.82	ADK (0.48)	ADKPRMT5METTL3DOT1LPRMT3
SCHEMBL29611067	0.82	ADK (0.48)	ADKPRMT5METTL3DOT1LPRMT3
SCHEMBL18744635	0.80	ADK (0.56)	ADK
SCHEMBL16968466	0.80	ADK (0.56)	ADK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022074391-A1	COMPOUNDS INHIBITORS OF METTL3	STORM THERAPEUTICS LIMITED (GB)	2022-04-14	—	—	WO	disclosed