SCHEMBL29478319

SCHEMBL29478319

CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](F)[C@H](n2cc(Br)c3c(N)ncnc32)O[C@@H]1C=O

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ ADK P55263 4/20 0.47
▸ METTL3 Q86U44 15/20 0.46
▸ PRMT5 O14744 5/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29478317 0.91 ADK (0.47) ADKMETTL3PRMT5
SCHEMBL29611067 0.86 ADK (0.48) ADKMETTL3PRMT5
SCHEMBL24313824 0.86 ADK (0.48) ADKMETTL3PRMT5
SCHEMBL29478310 0.84 ADK (0.51) ADKMETTL3PRMT5
SCHEMBL29478322 0.83 ADK (0.54) ADKMETTL3PRMT5
SCHEMBL17106708 0.79 METTL3 (0.45) ADKMETTL3PRMT5
SCHEMBL30106843 0.77 CYP1A2 (0.36) METTL3PRMT5
SCHEMBL20938367 0.73 ADK (0.50) ADKMETTL3PRMT5
SCHEMBL29478316 0.72 ADK (0.63) ADKMETTL3PRMT5
SCHEMBL20938366 0.72 ADK (0.47) ADKMETTL3PRMT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022074391-A1 COMPOUNDS INHIBITORS OF METTL3 STORM THERAPEUTICS LIMITED (GB) 2022-04-14 — — WO disclosed
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