SCHEMBL29478315

SCHEMBL29478315

C=C[C@H]1O[C@@H](n2cc(Br)c3c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)ncnc32)C[C@@H]1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 1/20 0.31
▸ METTL3 Q86U44 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29478306 0.81 METTL3 (0.44) PRMT5METTL3
SCHEMBL29478312 0.80 METTL3 (0.45) METTL3
SCHEMBL24293607 0.76 ADK (0.34) METTL3
SCHEMBL29478326 0.76 ADK (0.34) METTL3
SCHEMBL17106708 0.75 METTL3 (0.45) PRMT5METTL3
SCHEMBL20692747 0.75 SRC (0.39) —
SCHEMBL29611126 0.72 METTL3 (0.46) PRMT5METTL3
SCHEMBL24313507 0.72 METTL3 (0.46) PRMT5METTL3
SCHEMBL889533 0.70 HIF1A (0.38) —
SCHEMBL12570158 0.69 HIF1A (0.37) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022074391-A1 COMPOUNDS INHIBITORS OF METTL3 STORM THERAPEUTICS LIMITED (GB) 2022-04-14 — — WO disclosed
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