Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 4/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GCG | P01275 | 4/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567290 | 0.79 | EGLN1 (0.38) | MELKEGLN1GCG | |
| SCHEMBL22736230 | 0.76 | GRM4 (0.38) | EGLN1GCG | |
| SCHEMBL29480721 | 0.76 | GRM4 (0.38) | EGLN1GCG | |
| SCHEMBL29480523 | 0.75 | ADORA2A (0.36) | EGLN1GCG | |
| SCHEMBL29480762 | 0.75 | MELK (0.38) | MELKEGLN1GCGFLT1FLT4 | |
| SCHEMBL29480652 | 0.74 | EGLN1 (0.34) | MELKEGLN1 | |
| SCHEMBL22735954 | 0.74 | EGLN1 (0.34) | MELKEGLN1 | |
| SCHEMBL22736339 | 0.72 | GRM4 (0.35) | EGLN1GCG | |
| SCHEMBL8630577 | 0.68 | MELK (1.00) | MELKCYP3A4CYP2C9 | |
| SCHEMBL19501370 | 0.64 | EGLN1 (0.51) | EGLN1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |