Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.35 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29381263 | 0.86 | ADORA2A (0.44) | NOTUMJAK3ADORA2AADORA1TTBK1 | |
| SCHEMBL2226029 | 0.86 | ADORA2A (0.44) | NOTUMJAK3ADORA2AADORA1TTBK1 | |
| Trifluoroacetic Acid SCHEMBL28780341 | 0.81 | RIPK1 (0.40) | NOTUMJAK3HRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL28330499 | 0.75 | NOTUM (0.48) | NOTUMJAK3TTBK1TTBK2JAK2 | |
| Trifluoroacetic Acid SCHEMBL29971319 | 0.75 | NOTUM (0.48) | NOTUMJAK3TTBK1TTBK2JAK2 | |
| Trifluoroacetic Acid SCHEMBL28810979 | 0.70 | PDE3B (0.38) | HRH4HRH3KDM4EHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL30533171 | 0.69 | L3MBTL1 (0.34) | HRH4HRH3KDM4EHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL3278943 | 0.68 | HRH4 (0.35) | HRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL567274 | 0.68 | NUDT1 (0.43) | NOTUMJAK3JAK2 | |
| SCHEMBL11610965 | 0.67 | ADORA2A (0.46) | NOTUMADORA2AADORA1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114144415-A | Pyridopyrimidine derivative and pharmaceutical composition for preventing or treating PI3 kinase-associated disease comprising same as active ingredient | 保宁制药株式会社 | 2022-03-04 | — | — | CN | claimed |