Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 1.00 |
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 1.00 |
| ▸ | DRD4 known ✓ | P21917 | 3/20 | 1.00 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 10/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 8/20 | 1.00 |
| ▸ | HTR1A | P08908 | 6/20 | 1.00 |
| ▸ | TP53 | P04637 | 5/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 5/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 5/20 | 1.00 |
| ▸ | DRD1 | P21728 | 5/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 5/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 5/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 5/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 5/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 1.00 |
| ▸ | MTOR | P42345 | 5/20 | 1.00 |
| ▸ | KDM1A | O60341 | 4/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 4/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 4/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promazine SCHEMBL29392545 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL9052694 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL27425063 | 0.98 | CYP2D6 (0.97) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL29390978 | 0.98 | LMNA (1.00) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL123418 | 0.98 | LMNA (1.00) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL27429489 | 0.98 | CYP2D6 (0.97) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL123419 | 0.97 | CYP2D6 (0.94) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL28239574 | 0.95 | CYP2D6 (0.91) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| SCHEMBL6865346 | 0.95 | CYP2D6 (0.90) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL6855138 | 0.91 | CYP2D6 (0.83) | CYP2D6CYP1A2HTR1ATP53DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10606 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| EP-4741451-A1 | METHOD FOR DEGRADING A VINYL POLYMER | Centre National de la Recherche Scientifique (FR) | 2026-05-13 | — | — | EP | claimed |
| US-12624036-B2 | Method of treating post-traumatic stress disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12624037-B2 | Method of treating agitation, aggressive behavior, and impulse control disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12611412-B2 | Targeting the TLK1/NEK1 axis in prostate cancer | BOARD OF SUPERVISORS OF LOUISANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2026-04-28 | — | — | US | claimed |
| US-12550885-B2 | Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells | UNIVERSITY OF CINCINNATI (US) | 2026-02-17 | — | — | US | claimed |
| US-20260034065-A1 | EXTENDED RELEASE PHARMACEUTICAL FORMULATION | DOUGLAS PHARMACEUTICALS LTD (NZ) | 2026-02-05 | — | — | US | claimed |
| EP-4658278-A1 | SELECTIVE FIASMA TREATMENT | Valo Health, Inc. (US) | 2025-12-10 | — | — | EP | claimed |
| EP-0263873-A4 | ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD. | AL-SIOUFI HABIB | 1989-07-11 | — | — | EP | claimed |
| EP-0160806-B1 | PREPOLYMERS PREPARED FROM HYDROXY-AROMATIC MONO-ALDEHYDES AND METHYLATED PYRIDINES OR PYRAZINES, AND COMPOSITES PREPARED THEREFROM | THE DOW CHEMICAL COMPANY (US) | 1989-02-08 | — | — | EP | claimed |
| EP-0263873-A1 | ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD | AL-SIOUFI, Habib (US) | 1988-04-20 | — | — | EP | claimed |
| WO-1987006119-A1 | ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD | AL SIOUFI HABIB | 1987-10-22 | — | — | WO | claimed |
| EP-0174342-A1 | BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES. | UNIV FLORIDA (US) | 1986-03-19 | — | — | EP | claimed |
| WO-1985003937-A1 | BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES | UNIVERSITY OF FLORIDA (US) | 1985-09-12 | — | — | WO | claimed |
| EP-0089948-B1 | PHARMACEUTICAL COMPOSITIONS | COPPEN, Alec James (GB) | 1985-08-14 | — | — | EP | claimed |
| US-4407800-A | TRYPANOCIDES | UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION (US) | 1983-10-04 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-3993072-A | Microporous drug delivery device | ALZA CORPORATION (US) | 1976-11-23 | — | — | US | claimed |