Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | TYR | P14679 | 1/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAOB | P27338 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA3 | P07451 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL971515 | 1.00 | CYP2A6 (0.58) | CYP2A6HPGDSMN1; SMN2TYRDAO | |
| Thiophene SCHEMBL16099946 | 0.90 | MAOB (0.49) | CYP2A6HPGDSMN1; SMN2TYRDAO | |
| SCHEMBL7025703 | 0.87 | MAOB (0.55) | CYP2A6HPGDSMN1; SMN2TYRDAO | |
| SCHEMBL31678943 | 0.83 | HPGD (0.55) | CYP2A6HPGDSMN1; SMN2TYRDAO | |
| SCHEMBL15226687 | 0.83 | HPGD (0.59) | CYP2A6HPGDSMN1; SMN2TYRDAO | |
| SCHEMBL15226969 | 0.83 | SMN1; SMN2 (0.59) | CYP2A6HPGDSMN1; SMN2TYRDAO | |
| SCHEMBL4121645 | 0.83 | HPGD (0.55) | CYP2A6HPGDSMN1; SMN2TYRDAO | |
| Methylpiperazine SCHEMBL28392960 | 0.83 | KDM4E (0.50) | CYP2A6HPGDSMN1; SMN2TYRDAO | |
| SCHEMBL21949338 | 0.80 | SMN1; SMN2 (0.56) | CYP2A6HPGDSMN1; SMN2TYRDAO | |
| SCHEMBL28379349 | 0.80 | HPGD (0.51) | CYP2A6HPGDSMN1; SMN2TYRDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12570661-B2 | Isoform-specific aldehyde dehydrogenase inhibitors | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2026-03-10 | — | — | US | disclosed |
| EP-4155300-B1 | SUBSTITUTED QUINOLINE ANALOGS AS ALDEHYDE DEHYDROGENASE 1A1 (ALDH1A1) INHIBITORS | US HEALTH (US) | 2026-02-11 | — | — | EP | disclosed |
| CN-120077031-A | Prodrug kit for multitube concurrent chemotherapy | 亚历克斯·祖内克 | 2025-05-30 | — | — | CN | disclosed |
| US-11795177-B2 | Substituted quinoline analogs as aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-10-24 | — | — | US | disclosed |
| US-20230174537-A1 | Isoform-Specific Aldehyde Dehydrogenase Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-06-08 | — | — | US | disclosed |
| EP-4167995-A1 | ISOFORM-SPECIFIC ALDEHYDE DEHYDROGENASE INHIBITORS | The Board of Trustees of the Leland Stanford Junior University (US) | 2023-04-26 | — | — | EP | disclosed |
| EP-4155300-A1 | SUBSTITUTED QUINOLINE ANALOGS AS ALDEHYDE DEHYDROGENASE 1A1 (ALDH1A1) INHIBITORS | The U.S.A. as represented by the Secretary, Department of Health and Human Services (US) | 2023-03-29 | — | — | EP | disclosed |
| US-20230079399-A1 | SUBSTITUTED QUINOLINE ANALOGS AS ALDEHYDE DEHYDROGENASE 1A1 (ALDH1A1) INHIBITORS | THE US SECRETARY DEPARTMENT OF H (US) | 2023-03-16 | — | — | US | disclosed |
| US-11505559-B2 | Substituted quinoline analogs as aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH (US) | 2022-11-22 | — | — | US | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| CN-115215891-A | Trimeric indenyl bridged perylene diimide-coumarin-boron dipyrrole star compound and preparation method thereof | 南京林业大学 | 2022-10-21 | — | — | CN | disclosed |
| CN-110650961-B | PARP inhibitor, pharmaceutical composition, preparation method and application thereof | 广州丹康医药生物有限公司 | 2022-09-27 | — | — | CN | disclosed |
| US-20220133668-A1 | ISOTOPICALLY MODIFIED COMPONENTS AND THERAPEUTIC USES THEREOF | BIOJIVA LLC | 2022-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11795177-B2 | Substituted quinoline analogs as aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors | ALDH1A1, ALDH1A2, ALDH1B1 | CYP2A6 763/4885HPGD 189/4885SMN1; SMN2 4067/4885 |
| US-12570661-B2 | Isoform-specific aldehyde dehydrogenase inhibitors | ALDH3A1, ALDH1A1, ALDH1B1 | CYP2A6 245/4885HPGD 82/4885SMN1; SMN2 1517/4885 |
| US-20230079399-A1 | SUBSTITUTED QUINOLINE ANALOGS AS ALDEHYDE DEHYDROGENASE 1A1 (ALDH1A1) INHIBITORS | ALDH1A1, ALDH1A2, ALDH2 | CYP2A6 876/4885HPGD 98/4885SMN1; SMN2 4489/4885 |
| US-11505559-B2 | Substituted quinoline analogs as aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors | ALDH1A1, ALDH1A2, ALDH1B1 | CYP2A6 763/4885HPGD 189/4885SMN1; SMN2 4067/4885 |
| US-20220133668-A1 | ISOTOPICALLY MODIFIED COMPONENTS AND THERAPEUTIC USES THEREOF | ACADM, CPT1A, ALDH2 | CYP2A6 137/4885HPGD 139/4885SMN1; SMN2 1258/4885 |
| US-20230174537-A1 | Isoform-Specific Aldehyde Dehydrogenase Inhibitors | ALDH3A1, ALDH1A1, ALDH1B1 | CYP2A6 882/4885HPGD 68/4885SMN1; SMN2 2007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.