Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL146258 | 1.00 | KDM4E (0.62) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL14907284 | 0.89 | KDM4E (0.49) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16118574 | 0.85 | NPC1 (0.47) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1179412 | 0.85 | HTT (0.58) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL382822 | 0.84 | KDM4E (0.66) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL28365855 | 0.84 | ALDH1A1 (0.54) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL21994466 | 0.84 | ACHE (0.54) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16540058 | 0.84 | KDM4E (0.45) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3481145 | 0.84 | HPGD (0.58) | KDM4ENPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL11615858 | 0.84 | ALDH1A1 (0.46) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| EP-3989966-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |