Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tazarotene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB known ✓ | P10826 | 16/20 | 0.90 |
| ▸ | RARA known ✓ | P10276 | 15/20 | 0.90 |
| ▸ | RARG known ✓ | P13631 | 13/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.69 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tazarotene SCHEMBL3134 | 0.95 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL5747908 | 0.95 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL29397163 | 0.95 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL29512592 | 0.95 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL6101987 | 0.94 | RARA (0.98) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL995330 | 0.89 | RARB (0.88) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL9333830 | 0.87 | RARB (0.86) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL8037155 | 0.86 | RARA (0.83) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL19560666 | 0.85 | RARA (0.82) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL995895 | 0.85 | RARB (0.81) | RARBRARARARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040005575-A1 | Nucleic acids, proteins, and antibodies | HUMAN GENOME SCIENCES, INC. (US) | 2004-01-08 | — | — | US | disclosed |