Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | DAB2IP | Q5VWQ8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8028903 | 1.00 | MAOA (0.43) | MAOAMAOBOPRM1HTR1ADRD2 | |
| SCHEMBL21726113 | 0.79 | MAOA (0.41) | MAOAMAOBOPRM1HTR1ADRD2 | |
| SCHEMBL6650511 | 0.75 | HTR1A (0.39) | MAOAMAOBOPRM1HTR1ADRD2 | |
| SCHEMBL6650509 | 0.75 | HTR1A (0.39) | MAOAMAOBOPRM1HTR1ADRD2 | |
| SCHEMBL26304560 | 0.75 | ALDH1A1 (0.37) | OPRM1ALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL26956225 | 0.75 | BRD4 (0.42) | SMN1; SMN2KMT2ABRD4 | |
| SCHEMBL26956222 | 0.75 | BRD4 (0.42) | SMN1; SMN2KMT2ABRD4 | |
| SCHEMBL7656239 | 0.75 | NR1H2 (0.35) | OPRM1ALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL29515878 | 0.74 | ABHD6 (0.36) | ALDH1A1KMT2AHSD17B10HPGD | |
| SCHEMBL26956223 | 0.74 | ABHD6 (0.36) | ALDH1A1KMT2AHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240363-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | Merck Sharp & Dohme LLC (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098806-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | MERCK SHARP & DOHME CORP. (US) | 2022-05-12 | — | — | WO | disclosed |