Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.54 |
| ▸ | RXRB | P28702 | 1/20 | 0.54 |
| ▸ | RXRG | P48443 | 1/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.54 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2862455 | 0.90 | LDHA (0.65) | LDHANPC1RAB9ASMN1; SMN2SRD5A2 | |
| SCHEMBL27344645 | 0.84 | KIF11 (0.63) | KIF11PPARAMCHR1 | |
| SCHEMBL29994366 | 0.83 | MRGPRX4 (0.57) | LDHANPC1RAB9ASRD5A2RXRA | |
| SCHEMBL29690424 | 0.82 | KIF11 (0.61) | KIF11PPARAMCHR1TRPV1 | |
| SCHEMBL28530523 | 0.82 | KIF11 (0.61) | KIF11PPARAMCHR1TRPV1 | |
| SCHEMBL27702481 | 0.82 | RXFP1 (0.66) | LDHANPC1SRD5A2CYP2C8KIF11 | |
| SCHEMBL2952112 | 0.82 | LMNA (0.64) | NPC1RAB9ASMN1; SMN2KIF11MCHR1 | |
| SCHEMBL4469861 | 0.81 | RXRA (0.59) | NPC1RAB9ASMN1; SMN2SRD5A2RXRA | |
| SCHEMBL3187929 | 0.81 | KIF11 (0.51) | KIF11MAP4K4PPARAMCHR1 | |
| SCHEMBL4342508 | 0.81 | KIF11 (0.59) | KIF11PPARAMCHR1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2785707-B1 | NOVEL 2H-INDAZOLES AS EP2 RECEPTOR ANTAGONISTS | BAYER IP GMBH (DE) | 2018-01-24 | — | — | EP | disclosed |
| US-9655887-B2 | Pharmaceutical composition and the use thereof, and application regime of said pharmaceutical composition for on-demand contraception | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-23 | — | — | US | disclosed |
| US-20160089364-A1 | PHARMACEUTICAL COMPOSITION AND THE USE THEREOF, AND APPLICATION REGIME OF SAID PHARMACEUTICAL COMPOSITION FOR ON-DEMAND CONTRACEPTION | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-03-31 | — | — | US | disclosed |
| EP-2999469-A1 | PHARMACEUTICAL COMPOSITION AND THE USE THEREOF, AND APPLICATION REGIME OF SAID PHARMACEUTICAL COMPOSITION FOR ON-DEMAND CONTRACEPTION | Bayer Pharma Aktiengesellschaft (DE) | 2016-03-30 | — | — | EP | disclosed |
| US-9062041-B2 | 2H-indazoles as EP2 receptor antagonists | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-06-23 | — | — | US | disclosed |
| WO-2014187744-A1 | PHARMACEUTICAL COMPOSITION AND THE USE THEREOF, AND APPLICATION REGIME OF SAID PHARMACEUTICAL COMPOSITION FOR ON-DEMAND CONTRACEPTION | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-11-27 | — | — | WO | disclosed |
| US-20140336172-A1 | Novel 2H-Indazoles as EP2 Receptor Antagonists | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-11-13 | — | — | US | disclosed |
| EP-2785707-A1 | NOVEL 2H-INDAZOLES AS EP2 RECEPTOR ANTAGONISTS | Bayer Intellectual Property GmbH (DE) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013079425-A1 | NOVEL 2H-INDAZOLES AS EP2 RECEPTOR ANTAGONISTS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-06-06 | — | — | WO | disclosed |
| US-8324250-B2 | Piperidine derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-7504512-B2 | N-acylsulfonamide apoptosis promoters | ABBOTT LABORATORIES (US) | 2009-03-17 | — | — | US | disclosed |
| CN-100418965-C | Imidazopyridine derivatives | BANYU PHARMA CO LTD (JP) | 2008-09-17 | — | — | CN | disclosed |
| US-20080200494-A1 | Imidazopyridine Derivatives | MSD K.K. (JP) | 2008-08-21 | — | — | US | disclosed |
| CN-1835950-A | Imidazopyridine derivatives | BANYU PHARMA CO LTD (JP) | 2006-09-20 | — | — | CN | disclosed |
| EP-1657242-A1 | IMIDAZOPYRIDINE DERIVATIVES | Banyu Pharmaceutical Co., Ltd. (JP) | 2006-05-17 | — | — | EP | disclosed |
| EP-1318978-B1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2006-02-08 | — | — | EP | disclosed |
| US-20040192681-A1 | N-acylsulfonamide apoptosis promoters | ABBVIE INC. | 2004-09-30 | — | — | US | disclosed |
| US-6720338-B2 | BCL-X1 INHIBITING COMPOSITIONS AND METHODS OF PROMOTING APOPTOSIS IN A MAMMAL | ABBOTT LABORATORIES | 2004-04-13 | — | — | US | disclosed |
| US-20020086887-A1 | N-Acylsulfonamide apoptosis promoters | ABBVIE INC. | 2002-07-04 | — | — | US | disclosed |
| US-20020055631-A1 | N-acylsulfonamide apoptosis promoters | ABBOTT LABORATORIES | 2002-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020086887-A1 | N-Acylsulfonamide apoptosis promoters | BAX, BCLAF1, BCL2 | LDHA 4064/4885NPC1 2540/4885RAB9A 4211/4885 |
| US-20020055631-A1 | N-acylsulfonamide apoptosis promoters | BAX, BCLAF1, BCL2 | LDHA 3848/4885NPC1 2435/4885RAB9A 3769/4885 |
| US-20040192681-A1 | N-acylsulfonamide apoptosis promoters | BAX, BCLAF1, BCL2 | LDHA 4064/4885NPC1 2540/4885RAB9A 4211/4885 |
| US-20080200494-A1 | Imidazopyridine Derivatives | MC1R, MC3R, MC5R | LDHA 2802/4885NPC1 2382/4885RAB9A 1979/4885 |
| US-20160089364-A1 | PHARMACEUTICAL COMPOSITION AND THE USE THEREOF, AND APPLICATION REGIME OF SAID PHARMACEUTICAL COMPOSITION FOR ON-DEMAND CONTRACEPTION | PTGER2, PTGER3, PTGER1 | LDHA 4623/4885NPC1 3368/4885RAB9A 4408/4885 |
| US-20140336172-A1 | Novel 2H-Indazoles as EP2 Receptor Antagonists | PTGER2, PTGER1, PTGDR2 | LDHA 3961/4885NPC1 1720/4885RAB9A 3106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.